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• W4285092785 abstract "Normal breast luminal epithelial progenitors have been implicated as cell of origin in basal-like breast cancer, but their anatomical localization remains understudied. Here, we combine collection under the microscope of organoids from reduction mammoplasties and single-cell mRNA sequencing (scRNA-seq) of FACS-sorted luminal epithelial cells with multicolor imaging to profile ducts and terminal duct lobular units (TDLUs) and compare them with breast cancer subtypes. Unsupervised clustering reveals eleven distinct clusters and a differentiation trajectory starting with keratin 15+ (K15+) progenitors enriched in ducts. Spatial mapping of luminal progenitors is confirmed at the protein level by staining with critical duct markers. Comparison of the gene expression profiles of normal luminal cells with those of breast cancer subtypes suggests a strong correlation between normal breast ductal progenitors and basal-like breast cancer. We propose that K15+ basal-like breast cancers originate in ductal progenitors, which emphasizes the importance of not only lineages but also cellular position within the ductal-lobular tree." @default.
• W4285092785 created "2022-07-14" @default.
• W4285092785 creator A5005494301 @default.
• W4285092785 creator A5025120000 @default.
• W4285092785 creator A5025629360 @default.
• W4285092785 creator A5027489859 @default.
• W4285092785 creator A5030875398 @default.
• W4285092785 creator A5050322338 @default.
• W4285092785 creator A5063199220 @default.
• W4285092785 creator A5080136004 @default.
• W4285092785 creator A5084259371 @default.
• W4285092785 date "2022-07-12" @default.
• W4285092785 modified "2023-10-14" @default.
• W4285092785 title "Ductal keratin 15+ luminal progenitors in normal breast exhibit a basal-like breast cancer transcriptomic signature" @default.
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