Matches in SemOpenAlex for { <https://semopenalex.org/work/W4285092947> ?p ?o ?g. }
- W4285092947 endingPage "1680" @default.
- W4285092947 startingPage "1680" @default.
- W4285092947 abstract "Advanced endometrial cancer (EC) lacks therapy, thus, there is a need for novel treatment targets. CXCR4 overexpression is associated with a poor prognosis in several cancers, whereas its inhibition prevents metastases. We assessed CXCR4 expression in EC in women by using IHC. Orthotopic models were generated with transendometrial implantation of CXCR4-transduced EC cells. After in vitro evaluation of the CXCR4-targeted T22-GFP-H6 nanocarrier, subcutaneous EC models were used to study its uptake in tumor and normal organs. Of the women, 91% overexpressed CXCR4, making them candidates for CXCR4-targeted therapies. Thus, we developed CXCR4+ EC mouse models to improve metastagenesis compared to current models and to use them to develop novel CXCR4-targeted therapies for unresponsive EC. It showed enhanced dissemination, especially in the lungs and liver, and displayed 100% metastasis penetrance at all clinically relevant sites with anti-hVimentin IHC, improving detection sensitivity. Regarding the CXCR4-targeted nanocarrier, 60% accumulated in the SC tumor; therefore, selectively targeting CXCR4+ cancer cells, without toxicity in non-tumor organs. Our CXCR4+ EC models will allow testing of novel CXCR4-targeted drugs and development of nanomedicines derived from T22-GFP-H6 to deliver drugs to CXCR4+ cells in advanced EC. This novel approach provides a therapeutic option for women with metastatic, high risk or recurrent EC that have a dismal prognosis and lack effective therapies." @default.
- W4285092947 created "2022-07-14" @default.
- W4285092947 creator A5004513210 @default.
- W4285092947 creator A5018110872 @default.
- W4285092947 creator A5019007988 @default.
- W4285092947 creator A5019753819 @default.
- W4285092947 creator A5029892045 @default.
- W4285092947 creator A5041180389 @default.
- W4285092947 creator A5041996335 @default.
- W4285092947 creator A5042249122 @default.
- W4285092947 creator A5057173260 @default.
- W4285092947 creator A5057998635 @default.
- W4285092947 creator A5064844959 @default.
- W4285092947 creator A5082780934 @default.
- W4285092947 creator A5090326207 @default.
- W4285092947 date "2022-07-12" @default.
- W4285092947 modified "2023-10-17" @default.
- W4285092947 title "Novel Endometrial Cancer Models Using Sensitive Metastasis Tracing for CXCR4-Targeted Therapy in Advanced Disease" @default.
- W4285092947 cites W1120628463 @default.
- W4285092947 cites W1964984201 @default.
- W4285092947 cites W1999942080 @default.
- W4285092947 cites W2010568983 @default.
- W4285092947 cites W2014268454 @default.
- W4285092947 cites W2021564458 @default.
- W4285092947 cites W2037799556 @default.
- W4285092947 cites W2041440766 @default.
- W4285092947 cites W2055217104 @default.
- W4285092947 cites W2068186422 @default.
- W4285092947 cites W2073082981 @default.
- W4285092947 cites W2080062408 @default.
- W4285092947 cites W2106787323 @default.
- W4285092947 cites W2254136203 @default.
- W4285092947 cites W2302249892 @default.
- W4285092947 cites W2306750956 @default.
- W4285092947 cites W2338733771 @default.
- W4285092947 cites W2403023453 @default.
- W4285092947 cites W2414713280 @default.
- W4285092947 cites W2526864375 @default.
- W4285092947 cites W2566465729 @default.
- W4285092947 cites W2597022427 @default.
- W4285092947 cites W2740409075 @default.
- W4285092947 cites W2751779876 @default.
- W4285092947 cites W2766262050 @default.
- W4285092947 cites W2774088972 @default.
- W4285092947 cites W2885434554 @default.
- W4285092947 cites W2886088675 @default.
- W4285092947 cites W2886324201 @default.
- W4285092947 cites W2888855725 @default.
- W4285092947 cites W2952481429 @default.
- W4285092947 cites W2955353601 @default.
- W4285092947 cites W3010032766 @default.
- W4285092947 cites W3011192643 @default.
- W4285092947 cites W3016507081 @default.
- W4285092947 cites W3031116181 @default.
- W4285092947 cites W3044558890 @default.
- W4285092947 cites W3080768205 @default.
- W4285092947 cites W3091889220 @default.
- W4285092947 cites W3128646645 @default.
- W4285092947 cites W3134538122 @default.
- W4285092947 cites W3173418683 @default.
- W4285092947 cites W3204990520 @default.
- W4285092947 cites W3208703781 @default.
- W4285092947 cites W3213916205 @default.
- W4285092947 cites W1974670028 @default.
- W4285092947 doi "https://doi.org/10.3390/biomedicines10071680" @default.
- W4285092947 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/35884987" @default.
- W4285092947 hasPublicationYear "2022" @default.
- W4285092947 type Work @default.
- W4285092947 citedByCount "4" @default.
- W4285092947 countsByYear W42850929472022 @default.
- W4285092947 countsByYear W42850929472023 @default.
- W4285092947 crossrefType "journal-article" @default.
- W4285092947 hasAuthorship W4285092947A5004513210 @default.
- W4285092947 hasAuthorship W4285092947A5018110872 @default.
- W4285092947 hasAuthorship W4285092947A5019007988 @default.
- W4285092947 hasAuthorship W4285092947A5019753819 @default.
- W4285092947 hasAuthorship W4285092947A5029892045 @default.
- W4285092947 hasAuthorship W4285092947A5041180389 @default.
- W4285092947 hasAuthorship W4285092947A5041996335 @default.
- W4285092947 hasAuthorship W4285092947A5042249122 @default.
- W4285092947 hasAuthorship W4285092947A5057173260 @default.
- W4285092947 hasAuthorship W4285092947A5057998635 @default.
- W4285092947 hasAuthorship W4285092947A5064844959 @default.
- W4285092947 hasAuthorship W4285092947A5082780934 @default.
- W4285092947 hasAuthorship W4285092947A5090326207 @default.
- W4285092947 hasBestOaLocation W42850929471 @default.
- W4285092947 hasConcept C121608353 @default.
- W4285092947 hasConcept C126322002 @default.
- W4285092947 hasConcept C129470790 @default.
- W4285092947 hasConcept C13373296 @default.
- W4285092947 hasConcept C143998085 @default.
- W4285092947 hasConcept C170493617 @default.
- W4285092947 hasConcept C18150654 @default.
- W4285092947 hasConcept C2779013556 @default.
- W4285092947 hasConcept C2780035454 @default.
- W4285092947 hasConcept C2780492938 @default.
- W4285092947 hasConcept C2781230642 @default.
- W4285092947 hasConcept C502942594 @default.