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- W4285094080 abstract "The advances in transplant immunosuppression have reduced substantially the incidence of kidney graft rejection. In recent years, the focus has moved from preventing rejection to preventing the long-term consequences of long-standing immunosuppression, including nephrotoxicity induced by calcineurin inhibitors (CNI), as well as infectious and neoplastic complications. Since the appearance in the late 1990s of mTOR inhibitors (mTORi), these unmet needs in immunosuppression management could be addressed thanks to their benefits (reduced rate of viral infections and cancer). However, management of side effects can be troublesome and hands-on experience is needed. Here, we review all the available information about them. Thanks to all the basic, translational and clinical research achieved in the last twenty years, we now use mTORi as de novo immunosuppression in association with CNI. Another possibility is represented by the conversion of either CNI or mycophenolate (MPA) to an mTORi later on after transplantation in low-risk kidney transplant recipients." @default.
- W4285094080 created "2022-07-14" @default.
- W4285094080 creator A5000311687 @default.
- W4285094080 creator A5038633110 @default.
- W4285094080 creator A5053833967 @default.
- W4285094080 date "2022-07-12" @default.
- W4285094080 modified "2023-10-06" @default.
- W4285094080 title "Medical Aspects of mTOR Inhibition in Kidney Transplantation" @default.
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- W4285094080 doi "https://doi.org/10.3390/ijms23147707" @default.
- W4285094080 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/35887051" @default.
- W4285094080 hasPublicationYear "2022" @default.
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