FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4285094265> ?p ?o ?g. }

• W4285094265 abstract "Epithelial ovarian cancer (EOC) is one of the most lethal gynecological malignancies in women worldwide. G protein–coupled receptor 12 (GPR12) is a member of G protein–coupled receptors (GPCRs) and plays an important role in the regulation of cell proliferation and survival. However, its role in EOC is underappreciated. In this study, we found that GPR12 is highly expressed in the EOC tissues and can be an ideal biomarker to predict the prognosis of patients with EOC. GPR12 knockdown obviously inhibits the proliferation of EOC cells by inducing cellular apoptosis in vitro and in vivo . Meanwhile, bioinformatic analysis showed that the inhibitory effect of GPR12 knockdown on the cell viability is closely related with Extracellular signal-regulated kinases 1/2 (ERK1/2) pathway, which has been confirmed by the fact that the activity of ERK1/2 pathway has been significantly blocked in the GPR12 knockdown cells. LM22B-10, ERK1/2 pathway activator, could reverse the inhibited proliferation caused by GPR12 knockdown in the EOC cells. Our findings suggest that GPR12 is involved in the EOC process and is a potential therapeutic target for EOC." @default.
• W4285094265 created "2022-07-14" @default.
• W4285094265 creator A5002356899 @default.
• W4285094265 creator A5029484872 @default.
• W4285094265 creator A5065828212 @default.
• W4285094265 creator A5080577523 @default.
• W4285094265 date "2022-07-12" @default.
• W4285094265 modified "2023-10-03" @default.
• W4285094265 title "GPR12 Inhibits Apoptosis in Epithelial Ovarian Cancer via the Activation of ERK1/2 Signaling" @default.
• W4285094265 cites W1583472519 @default.
• W4285094265 cites W1879935490 @default.
• W4285094265 cites W1971548427 @default.
• W4285094265 cites W1974740818 @default.
• W4285094265 cites W2000253969 @default.
• W4285094265 cites W2008757142 @default.
• W4285094265 cites W2061009073 @default.
• W4285094265 cites W2064614289 @default.
• W4285094265 cites W2072338652 @default.
• W4285094265 cites W2081065429 @default.
• W4285094265 cites W2081145901 @default.
• W4285094265 cites W2082055785 @default.
• W4285094265 cites W2107100377 @default.
• W4285094265 cites W2108394200 @default.
• W4285094265 cites W2158025958 @default.
• W4285094265 cites W2163754094 @default.
• W4285094265 cites W2233325915 @default.
• W4285094265 cites W2239632319 @default.
• W4285094265 cites W2266474658 @default.
• W4285094265 cites W2507856777 @default.
• W4285094265 cites W2733836692 @default.
• W4285094265 cites W2777807685 @default.
• W4285094265 cites W2793972506 @default.
• W4285094265 cites W2890618112 @default.
• W4285094265 cites W2986121700 @default.
• W4285094265 cites W3000124456 @default.
• W4285094265 cites W3021731833 @default.
• W4285094265 cites W3099043519 @default.
• W4285094265 cites W3137304060 @default.
• W4285094265 cites W3144966281 @default.
• W4285094265 cites W3193275910 @default.
• W4285094265 doi "https://doi.org/10.3389/fonc.2022.932689" @default.
• W4285094265 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/35903681" @default.
• W4285094265 hasPublicationYear "2022" @default.
• W4285094265 type Work @default.
• W4285094265 citedByCount "0" @default.
• W4285094265 crossrefType "journal-article" @default.
• W4285094265 hasAuthorship W4285094265A5002356899 @default.
• W4285094265 hasAuthorship W4285094265A5029484872 @default.
• W4285094265 hasAuthorship W4285094265A5065828212 @default.
• W4285094265 hasAuthorship W4285094265A5080577523 @default.
• W4285094265 hasBestOaLocation W42850942651 @default.
• W4285094265 hasConcept C121608353 @default.
• W4285094265 hasConcept C126322002 @default.
• W4285094265 hasConcept C170493617 @default.
• W4285094265 hasConcept C173396325 @default.
• W4285094265 hasConcept C184235292 @default.
• W4285094265 hasConcept C185592680 @default.
• W4285094265 hasConcept C190283241 @default.
• W4285094265 hasConcept C2780427987 @default.
• W4285094265 hasConcept C502942594 @default.
• W4285094265 hasConcept C54355233 @default.
• W4285094265 hasConcept C55493867 @default.
• W4285094265 hasConcept C62112901 @default.
• W4285094265 hasConcept C62478195 @default.
• W4285094265 hasConcept C71924100 @default.
• W4285094265 hasConcept C86803240 @default.
• W4285094265 hasConcept C88045685 @default.
• W4285094265 hasConcept C95444343 @default.
• W4285094265 hasConceptScore W4285094265C121608353 @default.
• W4285094265 hasConceptScore W4285094265C126322002 @default.
• W4285094265 hasConceptScore W4285094265C170493617 @default.
• W4285094265 hasConceptScore W4285094265C173396325 @default.
• W4285094265 hasConceptScore W4285094265C184235292 @default.
• W4285094265 hasConceptScore W4285094265C185592680 @default.
• W4285094265 hasConceptScore W4285094265C190283241 @default.
• W4285094265 hasConceptScore W4285094265C2780427987 @default.
• W4285094265 hasConceptScore W4285094265C502942594 @default.
• W4285094265 hasConceptScore W4285094265C54355233 @default.
• W4285094265 hasConceptScore W4285094265C55493867 @default.
• W4285094265 hasConceptScore W4285094265C62112901 @default.
• W4285094265 hasConceptScore W4285094265C62478195 @default.
• W4285094265 hasConceptScore W4285094265C71924100 @default.
• W4285094265 hasConceptScore W4285094265C86803240 @default.
• W4285094265 hasConceptScore W4285094265C88045685 @default.
• W4285094265 hasConceptScore W4285094265C95444343 @default.
• W4285094265 hasFunder F4320321001 @default.
• W4285094265 hasLocation W42850942651 @default.
• W4285094265 hasLocation W42850942652 @default.
• W4285094265 hasLocation W42850942653 @default.
• W4285094265 hasOpenAccess W4285094265 @default.
• W4285094265 hasPrimaryLocation W42850942651 @default.
• W4285094265 hasRelatedWork W1794508113 @default.
• W4285094265 hasRelatedWork W2494327966 @default.
• W4285094265 hasRelatedWork W2531142332 @default.
• W4285094265 hasRelatedWork W2571047848 @default.
• W4285094265 hasRelatedWork W2699522849 @default.
• W4285094265 hasRelatedWork W2903968497 @default.
• W4285094265 hasRelatedWork W2980955790 @default.
• W4285094265 hasRelatedWork W3010357773 @default.
• W4285094265 hasRelatedWork W4296719734 @default.

• next