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- W4285095329 endingPage "S451" @default.
- W4285095329 startingPage "S429" @default.
- W4285095329 abstract "Chronological aging is by far the strongest risk factor for age-related dementia and Alzheimer’s disease. Senescent cells accumulated in the aging and Alzheimer’s disease brains are now recognized as the keys to describing such an association. Cellular senescence is a classic phenomenon characterized by stable cell arrest, which is thought to be applicable only to dividing cells. Emerging evidence indicates that fully differentiated post-mitotic neurons are also capable of becoming senescent, with roles in contributing to both brain aging and disease pathogenesis. The key question that arises is the identity of the upstream triggers and the molecular mechanisms that underly such changes. Here, we highlight the potential role of persistent DNA damage response as the major driver of senescent phenotypes and discuss the current evidence and molecular mechanisms that connect DNA repair infidelity, cell cycle re-entry and terminal fate decision in committing neuronal cell senescence." @default.
- W4285095329 created "2022-07-14" @default.
- W4285095329 creator A5028615605 @default.
- W4285095329 creator A5059908126 @default.
- W4285095329 date "2023-07-25" @default.
- W4285095329 modified "2023-10-18" @default.
- W4285095329 title "DNA Damage Response-Associated Cell Cycle Re-Entry and Neuronal Senescence in Brain Aging and Alzheimer’s Disease" @default.
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