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• W4285097551 abstract "Soft tissue sarcomas (STS) are a subset of sarcoma, a rare group of heterogeneous malignancies of mesenchymal origin. Current standard of care involves surgical resection with systemic chemotherapy used to treat high-risk localized and metastatic disease. Though classically thought to be immunologically quiet tumors, STS interact with the immune system, undergoing immunoediting that alters tumor immunogenicity and the tumor microenvironment. Recent advances with immune checkpoint inhibition have led to clinical trials exploring the efficacy of immunotherapy in treating STS. Results from these trials point to histologic subtype-specific clinical activity of immune checkpoint blockade. In addition, combinatorial strategies adding immune checkpoint inhibition to local or systemic therapies for STS have further increased their efficacy. Targeted immunotherapies using engineered T-cell receptor-based approaches also show increasing promise as treatment options for some patients with STS. Adoptive transfer of autologous T cells targeting NY-ESO-1 and MAGE-A4 have high response rates in sarcomas expressing these antigens, although recurrence is often seen in responding patients. Future work must focus on identifying primary and acquired mechanisms of resistance to these therapies, and extend T-cell receptor discovery to other tumor-associated antigens." @default.
• W4285097551 created "2022-07-14" @default.
• W4285097551 creator A5024939030 @default.
• W4285097551 creator A5089731384 @default.
• W4285097551 date "2022-07-01" @default.
• W4285097551 modified "2023-09-26" @default.
• W4285097551 title "The Role of Immunotherapy in the Management of Soft Tissue Sarcomas: Current Landscape and Future Outlook" @default.
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• W4285097551 cites W2032281778 @default.
• W4285097551 cites W2033005592 @default.
• W4285097551 cites W2059902820 @default.
• W4285097551 cites W2070748533 @default.
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• W4285097551 doi "https://doi.org/10.6004/jnccn.2022.7027" @default.
• W4285097551 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/35830892" @default.
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