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- W4285099054 abstract "Abstract Luteinizing hormone (LH) stimulates the synthesis and secretion of the key steroid hormone estrogen, which subsequently promotes ovarian follicular growth and development. Therefore, the administration of exogenous LH to achieve superovulation (multiple ovulations) and an LH surge is commonly used as the most effective therapeutic option in a majority of in vitro fertilization (IVF) clinics. However, a relatively low pregnancy rate (between 20% and 35%) is one of the most challenging aspects of LH-based infertility treatment. Furthermore, the major cause of this low pregnancy rate in LH-based infertility treatment remains unidentified. Recent studies have shown that endometrial stem cell loss or deficiency can significantly decrease tissue regeneration ability during the menstrual cycle and reduce endometrial receptivity. In this context, we postulated that the low pregnancy rates following LH-based ovarian hyperactivation may be the result of the adverse effects of consecutive exogenous LH administration on endometrial stem cells. To the best of our knowledge, this study revealed for the first time that in addition to its previously reported roles in stimulating ovarian functions through the pituitary-gonadal axis, LH brings about the extragonadal suppression of various tissue regeneration-associated functions in endometrial stem cells, such as self-renewal, migration ability, multilineage differentiation potential, and pluripotency/stemness, by inhibiting pro-survival Akt and ERK1/2 signaling pathways in vitro and in vivo, and as a consequence, it decreases the endometrial receptivity." @default.
- W4285099054 created "2022-07-14" @default.
- W4285099054 creator A5016656228 @default.
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- W4285099054 creator A5023832239 @default.
- W4285099054 creator A5040359894 @default.
- W4285099054 creator A5081853942 @default.
- W4285099054 date "2022-07-13" @default.
- W4285099054 modified "2023-10-16" @default.
- W4285099054 title "Novel roles of luteinizing hormone (LH) in tissue regeneration-associated functions in endometrial stem cells" @default.
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- W4285099054 doi "https://doi.org/10.1038/s41419-022-05054-7" @default.
- W4285099054 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/35831270" @default.
- W4285099054 hasPublicationYear "2022" @default.
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