Matches in SemOpenAlex for { <https://semopenalex.org/work/W4285100403> ?p ?o ?g. }
Showing items 1 to 90 of
90
with 100 items per page.
- W4285100403 endingPage "421" @default.
- W4285100403 startingPage "412" @default.
- W4285100403 abstract "抗CD38モノクローナル抗体（MoAb）製剤であるダラツムマブおよびイサツキシマブにより間接抗グロブリン試験は陽性となるが，直接抗グロブリン試験（DAT）に関しては不明な点が多い．我々はこれらの製剤が投与された多発性骨髄腫患者17例におけるDATを検討した．Tube法では15例が投与前陰性，Day1に9例が陽性化したが，Day6～8には再度陰性化した．CAT法では投与前に8例が陽性であり，Day1に15例が陽性となったが，Day6～8には陽性化した7例が全例陰性化した．患者赤血球のIgG結合量は16例でDay1に上昇し，Day6～8には前値近くまで復した．またCD38発現はDay1で約70%，Day6～8には約90%低下したことから，CD38の経時的な発現低下によりDay1で陽性化したDATは，Day6～8で陰性化すると考えられた．またヘモグロビン値は初回投与1日後で8.7%減少した．低濃度DTT処理赤血球の検討から，Day6～8にDAT陽性であった症例の多くは非特異的IgG結合によると思われた．多発性骨髄腫患者に対する抗CD38 MoAb製剤投与後のDATにはCD38発現の変化と非特異的IgG結合が影響するためその解釈を慎重に行う必要がある．" @default.
- W4285100403 created "2022-07-14" @default.
- W4285100403 creator A5000527626 @default.
- W4285100403 creator A5010594247 @default.
- W4285100403 creator A5011447551 @default.
- W4285100403 creator A5012177351 @default.
- W4285100403 creator A5030091429 @default.
- W4285100403 creator A5041425436 @default.
- W4285100403 creator A5041969161 @default.
- W4285100403 creator A5044439737 @default.
- W4285100403 creator A5051352722 @default.
- W4285100403 creator A5056927186 @default.
- W4285100403 creator A5059674526 @default.
- W4285100403 date "2022-06-24" @default.
- W4285100403 modified "2023-10-14" @default.
- W4285100403 title "DIRECT ANTIGLOBULIN TESTING OF PATIENTS WITH MULTIPLE MYELOMA TREATED WITH ANTI-CD38 MONOCLONAL ANTIBODIES" @default.
- W4285100403 cites W1641657728 @default.
- W4285100403 cites W1706622670 @default.
- W4285100403 cites W1902692042 @default.
- W4285100403 cites W2010658521 @default.
- W4285100403 cites W2072259475 @default.
- W4285100403 cites W2141502099 @default.
- W4285100403 cites W2229483068 @default.
- W4285100403 cites W2604547309 @default.
- W4285100403 cites W2764340845 @default.
- W4285100403 cites W2804650347 @default.
- W4285100403 cites W2891882983 @default.
- W4285100403 cites W2893844449 @default.
- W4285100403 cites W2914566915 @default.
- W4285100403 cites W2961368194 @default.
- W4285100403 cites W4234971900 @default.
- W4285100403 doi "https://doi.org/10.3925/jjtc.68.412" @default.
- W4285100403 hasPublicationYear "2022" @default.
- W4285100403 type Work @default.
- W4285100403 citedByCount "0" @default.
- W4285100403 crossrefType "journal-article" @default.
- W4285100403 hasAuthorship W4285100403A5000527626 @default.
- W4285100403 hasAuthorship W4285100403A5010594247 @default.
- W4285100403 hasAuthorship W4285100403A5011447551 @default.
- W4285100403 hasAuthorship W4285100403A5012177351 @default.
- W4285100403 hasAuthorship W4285100403A5030091429 @default.
- W4285100403 hasAuthorship W4285100403A5041425436 @default.
- W4285100403 hasAuthorship W4285100403A5041969161 @default.
- W4285100403 hasAuthorship W4285100403A5044439737 @default.
- W4285100403 hasAuthorship W4285100403A5051352722 @default.
- W4285100403 hasAuthorship W4285100403A5056927186 @default.
- W4285100403 hasAuthorship W4285100403A5059674526 @default.
- W4285100403 hasBestOaLocation W42851004031 @default.
- W4285100403 hasConcept C10205521 @default.
- W4285100403 hasConcept C159047783 @default.
- W4285100403 hasConcept C159654299 @default.
- W4285100403 hasConcept C159912055 @default.
- W4285100403 hasConcept C203014093 @default.
- W4285100403 hasConcept C2776364478 @default.
- W4285100403 hasConcept C28328180 @default.
- W4285100403 hasConcept C542903549 @default.
- W4285100403 hasConcept C54355233 @default.
- W4285100403 hasConcept C71924100 @default.
- W4285100403 hasConcept C86803240 @default.
- W4285100403 hasConceptScore W4285100403C10205521 @default.
- W4285100403 hasConceptScore W4285100403C159047783 @default.
- W4285100403 hasConceptScore W4285100403C159654299 @default.
- W4285100403 hasConceptScore W4285100403C159912055 @default.
- W4285100403 hasConceptScore W4285100403C203014093 @default.
- W4285100403 hasConceptScore W4285100403C2776364478 @default.
- W4285100403 hasConceptScore W4285100403C28328180 @default.
- W4285100403 hasConceptScore W4285100403C542903549 @default.
- W4285100403 hasConceptScore W4285100403C54355233 @default.
- W4285100403 hasConceptScore W4285100403C71924100 @default.
- W4285100403 hasConceptScore W4285100403C86803240 @default.
- W4285100403 hasIssue "3" @default.
- W4285100403 hasLocation W42851004031 @default.
- W4285100403 hasOpenAccess W4285100403 @default.
- W4285100403 hasPrimaryLocation W42851004031 @default.
- W4285100403 hasRelatedWork W1992624427 @default.
- W4285100403 hasRelatedWork W1998528865 @default.
- W4285100403 hasRelatedWork W1999686187 @default.
- W4285100403 hasRelatedWork W2024272351 @default.
- W4285100403 hasRelatedWork W2037651834 @default.
- W4285100403 hasRelatedWork W2071552617 @default.
- W4285100403 hasRelatedWork W2087924222 @default.
- W4285100403 hasRelatedWork W2143805675 @default.
- W4285100403 hasRelatedWork W2418298092 @default.
- W4285100403 hasRelatedWork W2435227317 @default.
- W4285100403 hasVolume "68" @default.
- W4285100403 isParatext "false" @default.
- W4285100403 isRetracted "false" @default.
- W4285100403 workType "article" @default.