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- W4285105103 endingPage "117864692210992" @default.
- W4285105103 startingPage "117864692210992" @default.
- W4285105103 abstract "Polycystic ovary syndrome (PCOS) is a complex metabolic disorder commonly seen in females of reproductive age. The pathophysiology of PCOS is multifactorial and includes dysfunction in ovarian steroidogenesis and folliculogenesis, impaired gonadotropin levels, insulin resistance, gut microbiota imbalance, genetic predisposition, and lifestyle preferences. Low-grade inflammatory conditions such as obesity and impaired glucose tolerance are common metabolic disturbances in women with PCOS. A growing body of literature suggests strong evidence rendering PCOS in close proximity with chronic inflammation as documented by high levels of serum white blood cells, C-reactive protein, and various proinflammatory cytokines seen in this condition. Inflammation seems to be the most common metabolic denominator between the kynurenine pathway and PCOS. The association of tryptophan and kynurenine pathway has already been well documented in mood disorders, neurodegenerative diseases, chronic pain conditions, and different inflammatory states. In this manuscript, we describe the influence of sex steroid hormones on different enzymes of the KP; inflammatory nature of PCOS and CRP as a marker of IDO/TDO activity; and the effects of altered gut flora in women with PCOS. This review provides a novel view of the available evidence of tryptophan and downstream metabolites in PCOS in the context of underlying inflammation." @default.
- W4285105103 created "2022-07-14" @default.
- W4285105103 creator A5026545881 @default.
- W4285105103 creator A5054475887 @default.
- W4285105103 creator A5076458014 @default.
- W4285105103 date "2022-01-01" @default.
- W4285105103 modified "2023-10-09" @default.
- W4285105103 title "The Kynurenine Pathway and Polycystic Ovary Syndrome: Inflammation as a Common Denominator" @default.
- W4285105103 cites W1489511844 @default.
- W4285105103 cites W1501881225 @default.
- W4285105103 cites W1551543102 @default.
- W4285105103 cites W1631763382 @default.
- W4285105103 cites W1650863056 @default.
- W4285105103 cites W1744368560 @default.
- W4285105103 cites W1766279404 @default.
- W4285105103 cites W1816148962 @default.
- W4285105103 cites W1830319888 @default.
- W4285105103 cites W1861040488 @default.
- W4285105103 cites W1971240021 @default.
- W4285105103 cites W1973239749 @default.
- W4285105103 cites W1973251492 @default.
- W4285105103 cites W1981645153 @default.
- W4285105103 cites W1987531976 @default.
- W4285105103 cites W1988314455 @default.
- W4285105103 cites W1999907967 @default.
- W4285105103 cites W2000450805 @default.
- W4285105103 cites W2003291376 @default.
- W4285105103 cites W2003598630 @default.
- W4285105103 cites W2007748602 @default.
- W4285105103 cites W2008869160 @default.
- W4285105103 cites W2009545032 @default.
- W4285105103 cites W2011888336 @default.
- W4285105103 cites W2013809984 @default.
- W4285105103 cites W2015248195 @default.
- W4285105103 cites W2024253268 @default.
- W4285105103 cites W2029933945 @default.
- W4285105103 cites W2039242155 @default.
- W4285105103 cites W2040501063 @default.
- W4285105103 cites W2042639777 @default.
- W4285105103 cites W2044620612 @default.
- W4285105103 cites W2047798386 @default.
- W4285105103 cites W2048726931 @default.
- W4285105103 cites W2049821596 @default.
- W4285105103 cites W2052820536 @default.
- W4285105103 cites W2053124968 @default.
- W4285105103 cites W2057689913 @default.
- W4285105103 cites W2058414104 @default.
- W4285105103 cites W2058561920 @default.
- W4285105103 cites W2058714321 @default.
- W4285105103 cites W2060415968 @default.
- W4285105103 cites W2063688039 @default.
- W4285105103 cites W2071384084 @default.
- W4285105103 cites W2076633494 @default.
- W4285105103 cites W2079199493 @default.
- W4285105103 cites W2091588936 @default.
- W4285105103 cites W2094313579 @default.
- W4285105103 cites W2094557907 @default.
- W4285105103 cites W2099581857 @default.
- W4285105103 cites W2101640392 @default.
- W4285105103 cites W2106824723 @default.
- W4285105103 cites W2109491705 @default.
- W4285105103 cites W2110627891 @default.
- W4285105103 cites W2111842746 @default.
- W4285105103 cites W2112553362 @default.
- W4285105103 cites W2118400891 @default.
- W4285105103 cites W2118614585 @default.
- W4285105103 cites W2119131931 @default.
- W4285105103 cites W2120760189 @default.
- W4285105103 cites W2122044177 @default.
- W4285105103 cites W2124343538 @default.
- W4285105103 cites W2130655121 @default.
- W4285105103 cites W2130780020 @default.
- W4285105103 cites W2131536322 @default.
- W4285105103 cites W2135200582 @default.
- W4285105103 cites W2139437936 @default.
- W4285105103 cites W2140987806 @default.
- W4285105103 cites W2142906957 @default.
- W4285105103 cites W2145355678 @default.
- W4285105103 cites W2147921405 @default.
- W4285105103 cites W2148378054 @default.
- W4285105103 cites W2151277589 @default.
- W4285105103 cites W2155897723 @default.
- W4285105103 cites W2157102763 @default.
- W4285105103 cites W2162502828 @default.
- W4285105103 cites W2168753438 @default.
- W4285105103 cites W2168847507 @default.
- W4285105103 cites W2170631284 @default.
- W4285105103 cites W2175810971 @default.
- W4285105103 cites W2186218348 @default.
- W4285105103 cites W2188779778 @default.
- W4285105103 cites W2245756097 @default.
- W4285105103 cites W2300755804 @default.
- W4285105103 cites W2339856074 @default.
- W4285105103 cites W2396164820 @default.
- W4285105103 cites W2419188583 @default.
- W4285105103 cites W2477760291 @default.
- W4285105103 cites W2523733243 @default.
- W4285105103 cites W2566392557 @default.