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- W4285118677 abstract "Type 1 diabetes (T1D) is an autoimmune disease caused by the immune-mediated destruction of insulin-producing pancreatic beta cells. However, the canonical notion that T1D is a beta-cell-specific and T-cell-mediated disease characterized by the complete loss of beta-cell mass and function has recently been questioned. Indeed, T1D is characterized by a remarkable interindividual heterogeneity in terms of genetic, pathophysiological, immunopathological, and metabolic features, which influence the clinical course and progression of the disease through its stages. In particular, age at diagnosis significantly correlates with distinct patterns of insulin processing (endotypes) and autoimmune responses (immunotypes) among T1D subjects. The immunopathological heterogeneity of T1D may also account for the heterogeneous response to immunotherapies observed across T1D subjects (theratypes). A better understanding of the disease heterogeneity will allow us to leverage translational and precision medicine by tailoring immunotherapies to specific pathophysiological processes observed in different subsets of T1D individuals." @default.
- W4285118677 created "2022-07-14" @default.
- W4285118677 creator A5013101960 @default.
- W4285118677 creator A5035428843 @default.
- W4285118677 creator A5059966253 @default.
- W4285118677 creator A5072930201 @default.
- W4285118677 date "2022-01-01" @default.
- W4285118677 modified "2023-10-18" @default.
- W4285118677 title "The heterogeneity of type 1 diabetes: From immunopathology to immune intervention" @default.
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