Matches in SemOpenAlex for { <https://semopenalex.org/work/W4285126861> ?p ?o ?g. }
- W4285126861 endingPage "4042" @default.
- W4285126861 startingPage "4026" @default.
- W4285126861 abstract "Podocyte injury is involved in the onset and progression of diabetic kidney disease (DKD) and is associated with mitochondrial abnormalities. Defective mitochondrial DNA (mtDNA) replication results in mitochondrial dysfunction. However, whether podocyte mtDNA replication is impaired in DKD is still unclear. A-kinase anchoring protein 1 (AKAP1) is localized in the outer mitochondrial membrane (OMM) and acts as a regulator and conductor of mitochondrial signals. Herein, we investigated the role of AKAP1 in high glucose-induced mtDNA replication. Decreased mtDNA replication and mitochondrial dysfunction occurred in podocytes of DKD. AKAP1 expression was up-regulated, and protein kinase C (PKC) signaling was activated under hyperglycemic conditions. AKAP1 recruited PKC and mediated La-related protein 1 (Larp1) phosphorylation, which reduced the expression of mitochondrial transcription factor A (TFAM), a key factor in mtDNA replication. In addition, mtDNA replication, mitochondrial function and podocyte injury were rescued by knocking down AKAP1 expression and the PKC inhibitor enzastaurin. In contrast, AKAP1 overexpression worsened the impairment of mtDNA replication and podocyte injury. In conclusion, our study revealed that AKAP1 phosphorylates Larp1 via PKC signaling activation to decrease mtDNA replication, which accelerates mitochondrial dysfunction and podocyte injury in DKD." @default.
- W4285126861 created "2022-07-14" @default.
- W4285126861 creator A5013359792 @default.
- W4285126861 creator A5021459859 @default.
- W4285126861 creator A5023563380 @default.
- W4285126861 creator A5037358505 @default.
- W4285126861 creator A5052074775 @default.
- W4285126861 creator A5052603260 @default.
- W4285126861 creator A5072352576 @default.
- W4285126861 creator A5074421810 @default.
- W4285126861 creator A5085736815 @default.
- W4285126861 date "2022-01-01" @default.
- W4285126861 modified "2023-10-18" @default.
- W4285126861 title "AKAP1 contributes to impaired mtDNA replication and mitochondrial dysfunction in podocytes of diabetic kidney disease" @default.
- W4285126861 cites W1971711320 @default.
- W4285126861 cites W2010668753 @default.
- W4285126861 cites W2017363253 @default.
- W4285126861 cites W2044176656 @default.
- W4285126861 cites W2134219545 @default.
- W4285126861 cites W2145323463 @default.
- W4285126861 cites W2180276344 @default.
- W4285126861 cites W2313521283 @default.
- W4285126861 cites W2465187827 @default.
- W4285126861 cites W2702602847 @default.
- W4285126861 cites W2738418450 @default.
- W4285126861 cites W2777580858 @default.
- W4285126861 cites W2788432017 @default.
- W4285126861 cites W2912424917 @default.
- W4285126861 cites W2913419387 @default.
- W4285126861 cites W2948153268 @default.
- W4285126861 cites W2948618629 @default.
- W4285126861 cites W2965173707 @default.
- W4285126861 cites W2973025652 @default.
- W4285126861 cites W2977605477 @default.
- W4285126861 cites W2979920977 @default.
- W4285126861 cites W2980411115 @default.
- W4285126861 cites W2985065511 @default.
- W4285126861 cites W2992856652 @default.
- W4285126861 cites W3006801832 @default.
- W4285126861 cites W3006847699 @default.
- W4285126861 cites W3029804467 @default.
- W4285126861 cites W3038802334 @default.
- W4285126861 cites W3081001956 @default.
- W4285126861 cites W3118809061 @default.
- W4285126861 cites W3118900618 @default.
- W4285126861 cites W3119347085 @default.
- W4285126861 cites W3127916746 @default.
- W4285126861 cites W3127993378 @default.
- W4285126861 cites W3130310782 @default.
- W4285126861 cites W3162745673 @default.
- W4285126861 cites W3178655647 @default.
- W4285126861 cites W3196178943 @default.
- W4285126861 cites W3202149821 @default.
- W4285126861 cites W3204527984 @default.
- W4285126861 cites W3205617958 @default.
- W4285126861 cites W3206696739 @default.
- W4285126861 cites W3210587964 @default.
- W4285126861 cites W3216038177 @default.
- W4285126861 cites W3217123170 @default.
- W4285126861 cites W3217666405 @default.
- W4285126861 cites W4200045574 @default.
- W4285126861 cites W4200076683 @default.
- W4285126861 cites W4200348337 @default.
- W4285126861 cites W4200368899 @default.
- W4285126861 cites W4200472142 @default.
- W4285126861 cites W4200510424 @default.
- W4285126861 cites W4206691162 @default.
- W4285126861 cites W4220775488 @default.
- W4285126861 cites W4221055219 @default.
- W4285126861 cites W4225164803 @default.
- W4285126861 cites W4225753310 @default.
- W4285126861 doi "https://doi.org/10.7150/ijbs.73493" @default.
- W4285126861 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/35844803" @default.
- W4285126861 hasPublicationYear "2022" @default.
- W4285126861 type Work @default.
- W4285126861 citedByCount "6" @default.
- W4285126861 countsByYear W42851268612022 @default.
- W4285126861 countsByYear W42851268612023 @default.
- W4285126861 crossrefType "journal-article" @default.
- W4285126861 hasAuthorship W4285126861A5013359792 @default.
- W4285126861 hasAuthorship W4285126861A5021459859 @default.
- W4285126861 hasAuthorship W4285126861A5023563380 @default.
- W4285126861 hasAuthorship W4285126861A5037358505 @default.
- W4285126861 hasAuthorship W4285126861A5052074775 @default.
- W4285126861 hasAuthorship W4285126861A5052603260 @default.
- W4285126861 hasAuthorship W4285126861A5072352576 @default.
- W4285126861 hasAuthorship W4285126861A5074421810 @default.
- W4285126861 hasAuthorship W4285126861A5085736815 @default.
- W4285126861 hasBestOaLocation W42851268611 @default.
- W4285126861 hasConcept C104317684 @default.
- W4285126861 hasConcept C134018914 @default.
- W4285126861 hasConcept C169415338 @default.
- W4285126861 hasConcept C24586158 @default.
- W4285126861 hasConcept C2777146197 @default.
- W4285126861 hasConcept C2777229759 @default.
- W4285126861 hasConcept C2779561371 @default.
- W4285126861 hasConcept C2780091579 @default.
- W4285126861 hasConcept C28859421 @default.