Matches in SemOpenAlex for { <https://semopenalex.org/work/W4285129503> ?p ?o ?g. }
- W4285129503 endingPage "305" @default.
- W4285129503 startingPage "277" @default.
- W4285129503 abstract "The three families of thiol- or selenol-based peroxidases (peroxiredoxins, Prx; glutathione peroxidases, GPx; and organic hydroperoxide resistance protein/osmotically inducible protein C, Ohr/OsmC) catalyze the reduction of hydroperoxides at the expense of thiol-containing compounds. In Prx, Ohr/OsmC, and some GPx, the catalysis involves a peroxidatic cysteine, while in other GPx, a selenocysteine. Their specificities for reducing and oxidizing substrates are distinct and may reflect their physiological roles. Prx and GPx share the thioredoxin fold common to the proteins belonging to the thioredoxin superfamily. In contrast, Ohr/OsmC present a unique barrel shape α/β fold. Some Prx change their oligomeric state under different conditions, including protein redox state, which is associated with a chaperone function. Ohr/OsmC are dimers and GPx can be monomeric or tetrameric, irrespective of their oxidation state. The mechanisms behind the extraordinary catalytic efficiency of these enzymes in the reduction of hydroperoxides are discussed." @default.
- W4285129503 created "2022-07-14" @default.
- W4285129503 creator A5010572858 @default.
- W4285129503 creator A5032784144 @default.
- W4285129503 creator A5032919449 @default.
- W4285129503 creator A5075100345 @default.
- W4285129503 date "2022-01-01" @default.
- W4285129503 modified "2023-09-30" @default.
- W4285129503 title "Thiol- and selenol-based peroxidases: Structure and catalytic properties" @default.
- W4285129503 cites W1486228890 @default.
- W4285129503 cites W149023422 @default.
- W4285129503 cites W1497318066 @default.
- W4285129503 cites W1500094754 @default.
- W4285129503 cites W1531285870 @default.
- W4285129503 cites W1545965226 @default.
- W4285129503 cites W1564031035 @default.
- W4285129503 cites W1588431186 @default.
- W4285129503 cites W1589043152 @default.
- W4285129503 cites W1595015475 @default.
- W4285129503 cites W1625092822 @default.
- W4285129503 cites W1658174274 @default.
- W4285129503 cites W1669539776 @default.
- W4285129503 cites W180409715 @default.
- W4285129503 cites W1806324607 @default.
- W4285129503 cites W1963668163 @default.
- W4285129503 cites W1965068472 @default.
- W4285129503 cites W1968943030 @default.
- W4285129503 cites W1969226797 @default.
- W4285129503 cites W1969436148 @default.
- W4285129503 cites W1969905639 @default.
- W4285129503 cites W1970227518 @default.
- W4285129503 cites W1970425360 @default.
- W4285129503 cites W1971966226 @default.
- W4285129503 cites W1972530911 @default.
- W4285129503 cites W1972702872 @default.
- W4285129503 cites W1973216203 @default.
- W4285129503 cites W1973744965 @default.
- W4285129503 cites W1973751658 @default.
- W4285129503 cites W1974601783 @default.
- W4285129503 cites W1974658879 @default.
- W4285129503 cites W1975984844 @default.
- W4285129503 cites W1976006396 @default.
- W4285129503 cites W1976087136 @default.
- W4285129503 cites W1977327543 @default.
- W4285129503 cites W1980886830 @default.
- W4285129503 cites W1981112109 @default.
- W4285129503 cites W1981786531 @default.
- W4285129503 cites W1982893940 @default.
- W4285129503 cites W1983311902 @default.
- W4285129503 cites W1983316037 @default.
- W4285129503 cites W1983400539 @default.
- W4285129503 cites W1984387620 @default.
- W4285129503 cites W1985048135 @default.
- W4285129503 cites W1987328222 @default.
- W4285129503 cites W1987686004 @default.
- W4285129503 cites W1993240748 @default.
- W4285129503 cites W1994500027 @default.
- W4285129503 cites W1994860086 @default.
- W4285129503 cites W1995889616 @default.
- W4285129503 cites W1995912615 @default.
- W4285129503 cites W1996053043 @default.
- W4285129503 cites W1997183854 @default.
- W4285129503 cites W1998294214 @default.
- W4285129503 cites W1999014341 @default.
- W4285129503 cites W1999382188 @default.
- W4285129503 cites W1999748325 @default.
- W4285129503 cites W2001755249 @default.
- W4285129503 cites W2002850755 @default.
- W4285129503 cites W2003625275 @default.
- W4285129503 cites W2007098177 @default.
- W4285129503 cites W2007239014 @default.
- W4285129503 cites W2007684558 @default.
- W4285129503 cites W2008613157 @default.
- W4285129503 cites W2008938522 @default.
- W4285129503 cites W2009476974 @default.
- W4285129503 cites W2009840636 @default.
- W4285129503 cites W2010422145 @default.
- W4285129503 cites W2015752748 @default.
- W4285129503 cites W2016241657 @default.
- W4285129503 cites W2017309092 @default.
- W4285129503 cites W2017370353 @default.
- W4285129503 cites W2017789801 @default.
- W4285129503 cites W2017906971 @default.
- W4285129503 cites W2018039069 @default.
- W4285129503 cites W2021417252 @default.
- W4285129503 cites W2023231364 @default.
- W4285129503 cites W2023670833 @default.
- W4285129503 cites W2025639892 @default.
- W4285129503 cites W2025885285 @default.
- W4285129503 cites W2030872095 @default.
- W4285129503 cites W2035713858 @default.
- W4285129503 cites W2036603507 @default.
- W4285129503 cites W2037083980 @default.
- W4285129503 cites W2037803313 @default.
- W4285129503 cites W2040193829 @default.
- W4285129503 cites W2041115865 @default.
- W4285129503 cites W2044075759 @default.
- W4285129503 cites W2045700862 @default.