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• W4285135126 startingPage "155" @default.
• W4285135126 abstract "Parkinson’s disease (PD) is the second most common neurodegenerative disorder of the elderly affecting around 1% of individuals older than 65 years of age. PD poses a major health and economic burden, due to its chronic and progressive nature and the lack of available effective medications to stop or even slow its progression. Majority of PD cases is not linked to known genetic mutations and could be related to environmental factors and an unhealthy lifestyle including deficiency of micronutrients like vitamin D. In the current work, we reviewed the literature to understand the role of vitamin D in the brain and the association between vitamin D insufficiency and deficiency and risk of developing PD. We focus on the molecular mechanisms explaining the increased PD risk concentrating on the nutrigenomic effects of vitamin D. Due to the fact that the prevalence of PD in Egypt is higher than the international one, vitamin D deficiency and some other modifiable risk factors for PD among the Egyptian were discussed. The potential therapeutic role of vitamin D for managing PD was further reviewed. Finally, we could draw the conclusion that vitamin D deficiency may be associated with an increase in the risk and progression of PD. More research is warranted to elucidate the role of vitamin D as preventive and therapeutic options for patients with PD." @default.
• W4285135126 created "2022-07-14" @default.
• W4285135126 creator A5000250008 @default.
• W4285135126 creator A5017818160 @default.
• W4285135126 creator A5079568126 @default.
• W4285135126 date "2022-01-01" @default.
• W4285135126 modified "2023-09-26" @default.
• W4285135126 title "The Emerging Role of Vitamin D Deficiency as a Risk Factor of Parkinson’s Disease" @default.
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