Matches in SemOpenAlex for { <https://semopenalex.org/work/W4285136637> ?p ?o ?g. }
- W4285136637 endingPage "100042" @default.
- W4285136637 startingPage "100042" @default.
- W4285136637 abstract "A critical challenge in current research on Alzheimer's disease (AD) is to clarify the relationship between network dysfunction and the emergence of subtle memory deficits in itspreclinical stage. The AppNL-F/MAPT double knock-in (dKI) model with humanized β-amyloid peptide (Aβ) and tau was used to investigate both memory and network dysfunctions at an early stage. Young male dKI mice (2 to 6 months) were tested in three tasks taxing different aspects of recognition memory affected in preclinical AD. An early deficit first appeared in the object-place association task at the age of 4 months, when increased levels of β-CTF and Aβ were detected in both the hippocampus and the medial temporal cortex, and tau pathology was found only in the medial temporal cortex. Object-place task-dependent c-Fos activation was then analyzed in 22 subregions across the medial prefrontal cortex, claustrum, retrosplenial cortex, and medial temporal lobe. Increased c-Fos activation was detected in the entorhinal cortex and the claustrum of dKI mice. During recall, network efficiency was reduced across cingulate regions with a major disruption of information flow through the retrosplenial cortex. Our findings suggest that early perirhinal-entorhinal pathology is associated with abnormal activity which may spread to downstream regions such as the claustrum, the medial prefrontal cortex and ultimately the key retrosplenial hub which relays information from frontal to temporal lobes. The similarity between our findings and those reported in preclinical stages of AD suggests that the AppNL-F/MAPT dKI model has a high potential for providing key insights into preclinical AD." @default.
- W4285136637 created "2022-07-14" @default.
- W4285136637 creator A5013301564 @default.
- W4285136637 creator A5014397233 @default.
- W4285136637 creator A5017477440 @default.
- W4285136637 creator A5020057785 @default.
- W4285136637 creator A5023317571 @default.
- W4285136637 creator A5028904221 @default.
- W4285136637 creator A5029357813 @default.
- W4285136637 creator A5050140715 @default.
- W4285136637 creator A5052081860 @default.
- W4285136637 creator A5063664912 @default.
- W4285136637 creator A5082483380 @default.
- W4285136637 creator A5082928676 @default.
- W4285136637 date "2022-01-01" @default.
- W4285136637 modified "2023-10-17" @default.
- W4285136637 title "Early memory deficits and extensive brain network disorganization in the App/MAPT double knock-in mouse model of familial Alzheimer’s disease" @default.
- W4285136637 cites W1486416255 @default.
- W4285136637 cites W1488741626 @default.
- W4285136637 cites W1719469090 @default.
- W4285136637 cites W1833523444 @default.
- W4285136637 cites W1918775028 @default.
- W4285136637 cites W1965771106 @default.
- W4285136637 cites W1966100017 @default.
- W4285136637 cites W1978593493 @default.
- W4285136637 cites W1980737965 @default.
- W4285136637 cites W1981271931 @default.
- W4285136637 cites W1986951455 @default.
- W4285136637 cites W1990313607 @default.
- W4285136637 cites W1991490575 @default.
- W4285136637 cites W1995227930 @default.
- W4285136637 cites W2022686017 @default.
- W4285136637 cites W2023768217 @default.
- W4285136637 cites W2031921419 @default.
- W4285136637 cites W2035462451 @default.
- W4285136637 cites W2036361806 @default.
- W4285136637 cites W2036617704 @default.
- W4285136637 cites W2043783389 @default.
- W4285136637 cites W2059066557 @default.
- W4285136637 cites W2060464767 @default.
- W4285136637 cites W2082807747 @default.
- W4285136637 cites W2083380131 @default.
- W4285136637 cites W2090620788 @default.
- W4285136637 cites W2101353854 @default.
- W4285136637 cites W2109726592 @default.
- W4285136637 cites W2116964904 @default.
- W4285136637 cites W2123491442 @default.
- W4285136637 cites W2124994926 @default.
- W4285136637 cites W2126691904 @default.
- W4285136637 cites W2128520379 @default.
- W4285136637 cites W2129497119 @default.
- W4285136637 cites W2131422138 @default.
- W4285136637 cites W2150481150 @default.
- W4285136637 cites W2155145921 @default.
- W4285136637 cites W2156954346 @default.
- W4285136637 cites W2165942026 @default.
- W4285136637 cites W2167160506 @default.
- W4285136637 cites W2167822639 @default.
- W4285136637 cites W2170725855 @default.
- W4285136637 cites W2180397831 @default.
- W4285136637 cites W2314722338 @default.
- W4285136637 cites W2403547050 @default.
- W4285136637 cites W2409128141 @default.
- W4285136637 cites W2461584436 @default.
- W4285136637 cites W2547689414 @default.
- W4285136637 cites W2590659146 @default.
- W4285136637 cites W2595643095 @default.
- W4285136637 cites W2600090485 @default.
- W4285136637 cites W2605615531 @default.
- W4285136637 cites W2606136976 @default.
- W4285136637 cites W2740213823 @default.
- W4285136637 cites W2754761896 @default.
- W4285136637 cites W2765197557 @default.
- W4285136637 cites W2766125374 @default.
- W4285136637 cites W2767500419 @default.
- W4285136637 cites W2767535310 @default.
- W4285136637 cites W2782939308 @default.
- W4285136637 cites W2787666045 @default.
- W4285136637 cites W2789586078 @default.
- W4285136637 cites W2792211318 @default.
- W4285136637 cites W2802161235 @default.
- W4285136637 cites W2803436652 @default.
- W4285136637 cites W2804318715 @default.
- W4285136637 cites W2807443525 @default.
- W4285136637 cites W2891090510 @default.
- W4285136637 cites W2904440485 @default.
- W4285136637 cites W2912476852 @default.
- W4285136637 cites W2913978847 @default.
- W4285136637 cites W2948560263 @default.
- W4285136637 cites W2948925924 @default.
- W4285136637 cites W2949219793 @default.
- W4285136637 cites W2949764031 @default.
- W4285136637 cites W2953216263 @default.
- W4285136637 cites W2954476098 @default.
- W4285136637 cites W2983664177 @default.
- W4285136637 cites W2991962829 @default.
- W4285136637 cites W3004620280 @default.
- W4285136637 cites W3015437269 @default.