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• W4285138088 endingPage "117727192211066" @default.
• W4285138088 startingPage "117727192211066" @default.
• W4285138088 abstract "Disruption in the natural immune reaction due to SARS-CoV-2 infection can initiate a potent cytokine storm among COVID-19 patients. An elevated level of IL-6 and IL-10 during a hyperinflammatory state plays a vital role in increasing the risk of severity and mortality. In this study, we aimed to evaluate the potential of circulating IL-6 and IL-10 levels as biomarkers for detecting the severity and mortality of COVID-19.This study was conducted according to the Cochrane Handbook and PRISMA guidelines. Authorized databases were searched to extract suitable studies using specific search terms. RevMan 5.4 was applied for performing the meta-analysis. Mean differences in IL-6 and IL-10 levels were calculated among COVID-19 patients via a random-effects model. NOS scoring, publication bias and sensitivity analyses were checked to ensure study quality.A total of 147 studies were selected, with 31 909 COVID-19 patients under investigation. In the severity analysis, the mean concentration of IL-6 was significantly higher in the severe COVID-19 cases than in the non-severe cases (MD: 19.98; P < .001; 95% CI: 17.56, 22.40). Similar result was observed for IL-10 mean concentration in severe COVID-19 cases (MD: 1.35; P < .001; 95% CI: 0.90, 1.80). In terms of mortality analysis, circulating IL-6 showed sharp elevation in the deceased patients (MD: 42.11; P < .001; 95% CI: 36.86, 47.36). IL-10 mean concentration was higher in the dead patients than in the survived patients (MD: 4.79; P < .001; 95% CI: 2.83, 6.75). Publication bias was not found except for comparing IL-6 levels with disease severity. Sensitivity analysis also reported no significant deviation from the pooled outcomes.Elevated levels of circulating IL-6 and IL-10 signifies worsening of COVID-19. To monitor the progression of SARS-CoV-2 infection, IL-6 and IL-10 should be considered as potential biomarkers for severity and mortality detection in COVID-19.INPLASY registration number: INPLASY202240046." @default.
• W4285138088 created "2022-07-14" @default.
• W4285138088 creator A5015307152 @default.
• W4285138088 creator A5063014537 @default.
• W4285138088 creator A5063970775 @default.
• W4285138088 date "2022-01-01" @default.
• W4285138088 modified "2023-09-30" @default.
• W4285138088 title "Elevated Levels of Pleiotropic Interleukin-6 (IL-6) and Interleukin-10 (IL-10) are Critically Involved With the Severity and Mortality of COVID-19: An Updated Longitudinal Meta-Analysis and Systematic Review on 147 Studies" @default.
• W4285138088 cites W1998010817 @default.
• W4285138088 cites W2057018521 @default.
• W4285138088 cites W2077726738 @default.
• W4285138088 cites W2156098321 @default.
• W4285138088 cites W246286872 @default.
• W4285138088 cites W2567362164 @default.
• W4285138088 cites W2978795816 @default.
• W4285138088 cites W2981657433 @default.
• W4285138088 cites W2981752008 @default.
• W4285138088 cites W3001118548 @default.
• W4285138088 cites W3007829007 @default.
• W4285138088 cites W3008691534 @default.
• W4285138088 cites W3008827533 @default.
• W4285138088 cites W3009314935 @default.
• W4285138088 cites W3009859788 @default.
• W4285138088 cites W3009885589 @default.
• W4285138088 cites W3009898265 @default.
• W4285138088 cites W3010617446 @default.
• W4285138088 cites W3010738632 @default.
• W4285138088 cites W3011223898 @default.
• W4285138088 cites W3011610993 @default.
• W4285138088 cites W3012374679 @default.
• W4285138088 cites W3012422150 @default.
• W4285138088 cites W3012492786 @default.
• W4285138088 cites W3012849736 @default.
• W4285138088 cites W3013243519 @default.
• W4285138088 cites W3013250171 @default.
• W4285138088 cites W3013668993 @default.
• W4285138088 cites W3013990344 @default.
• W4285138088 cites W3014003872 @default.
• W4285138088 cites W3014183762 @default.
• W4285138088 cites W3014275885 @default.
• W4285138088 cites W3014786535 @default.
• W4285138088 cites W3015198978 @default.
• W4285138088 cites W3015289726 @default.
• W4285138088 cites W3015599013 @default.
• W4285138088 cites W3016127406 @default.
• W4285138088 cites W3016493664 @default.
• W4285138088 cites W3016538467 @default.
• W4285138088 cites W3016746341 @default.
• W4285138088 cites W3016832871 @default.
• W4285138088 cites W3016961971 @default.
• W4285138088 cites W3017110669 @default.
• W4285138088 cites W3017119695 @default.
• W4285138088 cites W3017233408 @default.
• W4285138088 cites W3017251343 @default.
• W4285138088 cites W3017359394 @default.
• W4285138088 cites W3017756122 @default.
• W4285138088 cites W3018002710 @default.
• W4285138088 cites W3019187481 @default.
• W4285138088 cites W3020334311 @default.
• W4285138088 cites W3020501159 @default.
• W4285138088 cites W3021438911 @default.
• W4285138088 cites W3021915688 @default.
• W4285138088 cites W3022660304 @default.
• W4285138088 cites W3022926099 @default.
• W4285138088 cites W3023125802 @default.
• W4285138088 cites W3023752426 @default.
• W4285138088 cites W3023766230 @default.
• W4285138088 cites W3024251435 @default.
• W4285138088 cites W3024374346 @default.
• W4285138088 cites W3024607230 @default.
• W4285138088 cites W3025160648 @default.
• W4285138088 cites W3025283988 @default.
• W4285138088 cites W3025336075 @default.
• W4285138088 cites W3025353034 @default.
• W4285138088 cites W3025830962 @default.
• W4285138088 cites W3028311423 @default.
• W4285138088 cites W3030478153 @default.
• W4285138088 cites W3031362785 @default.
• W4285138088 cites W3031385170 @default.
• W4285138088 cites W3031797097 @default.
• W4285138088 cites W3032543466 @default.
• W4285138088 cites W3033194401 @default.
• W4285138088 cites W3033765823 @default.
• W4285138088 cites W3033922735 @default.
• W4285138088 cites W3034095150 @default.
• W4285138088 cites W3034328076 @default.
• W4285138088 cites W3034442225 @default.
• W4285138088 cites W3034585457 @default.
• W4285138088 cites W3035053306 @default.
• W4285138088 cites W3035643349 @default.
• W4285138088 cites W3036239415 @default.
• W4285138088 cites W3036563213 @default.
• W4285138088 cites W3036776724 @default.
• W4285138088 cites W3037470061 @default.
• W4285138088 cites W3037768701 @default.
• W4285138088 cites W3038905624 @default.
• W4285138088 cites W3039703269 @default.
• W4285138088 cites W3039912799 @default.

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