Matches in SemOpenAlex for { <https://semopenalex.org/work/W4285138557> ?p ?o ?g. }
Showing items 1 to 96 of
96
with 100 items per page.
- W4285138557 endingPage "4" @default.
- W4285138557 startingPage "4" @default.
- W4285138557 abstract "Background and Objectives: Older adults are more susceptible to coronavirus disease 2019 (COVID-19). Interleukin-6 (IL-6) is an important cytokine in the cytokine release syndrome (CRS), and tocilizumab blocks the IL-6 receptor. The objective is to analyze the effect of tocilizumab on CRS in older patients with severe COVID-19. Materials and Methods: Between February 10 and March 21, 2020, a total of 19 patients aged ≥60 years with severe or critical COVID-19 met the study inclusion criteria at the Tongji Hospital in Wuhan City, Hubei Province, China. The patients were divided into two groups: the tocilizumab group, with IL-6 levels, which exceeded the upper limit of normal by >10-fold and non-tocilizumab group. Results: Patients in the tocilizumab group were older (73.20 ± 4.44 vs. 66.21 ± 5.06 years, P = 0.014), had lower lymphocyte counts (0.71 ± 0.18 vs. 1.18 ± 0.59 × 109/L, P = 0.016), and higher high-sensitivity C-reactive protein (hsCRP) levels (94.04 ± 57.24 vs. 51.65 ± 45.37 mg/L, P = 0.035). Increases in ferritin (FER) and hsCRP levels in patients in the tocilizumab group were marked. Except for one patient who died, IL-6, FER, hsCRP levels, and the neutrophil/lymphocyte ratio in the remaining four patients decreased following treatment with tocilizumab. Tocilizumab did not cause any serious adverse reactions. There were no differences in mortality, days until lung computerized tomography improvement, or renal function between the two groups. The total mortality rate was 10.53%. Conclusions: Our results support the therapeutic efficacy and safety of tocilizumab in older patients with severe COVID-19." @default.
- W4285138557 created "2022-07-14" @default.
- W4285138557 creator A5001969147 @default.
- W4285138557 creator A5007979807 @default.
- W4285138557 creator A5019654932 @default.
- W4285138557 creator A5021687717 @default.
- W4285138557 creator A5026825966 @default.
- W4285138557 creator A5050238370 @default.
- W4285138557 creator A5057891766 @default.
- W4285138557 creator A5060883903 @default.
- W4285138557 creator A5062451757 @default.
- W4285138557 creator A5063213559 @default.
- W4285138557 creator A5072861783 @default.
- W4285138557 date "2022-12-01" @default.
- W4285138557 modified "2023-10-14" @default.
- W4285138557 title "Therapeutic Effect of Tocilizumab on Inhibiting Cytokine Release Syndrome in Severe Coronavirus Disease 2019 Patients" @default.
- W4285138557 cites W2082708772 @default.
- W4285138557 cites W2754562068 @default.
- W4285138557 cites W2796022095 @default.
- W4285138557 cites W3002108456 @default.
- W4285138557 cites W3011610993 @default.
- W4285138557 cites W3014003872 @default.
- W4285138557 cites W3014050022 @default.
- W4285138557 cites W3014130682 @default.
- W4285138557 cites W3014333693 @default.
- W4285138557 cites W3015228903 @default.
- W4285138557 cites W3015559628 @default.
- W4285138557 cites W3016263512 @default.
- W4285138557 cites W3016585006 @default.
- W4285138557 cites W3019471008 @default.
- W4285138557 cites W3019785070 @default.
- W4285138557 cites W3022970339 @default.
- W4285138557 cites W3031713996 @default.
- W4285138557 cites W3148096577 @default.
- W4285138557 cites W4206245015 @default.
- W4285138557 doi "https://doi.org/10.4103/imna.imna_5_22" @default.
- W4285138557 hasPublicationYear "2022" @default.
- W4285138557 type Work @default.
- W4285138557 citedByCount "0" @default.
- W4285138557 crossrefType "journal-article" @default.
- W4285138557 hasAuthorship W4285138557A5001969147 @default.
- W4285138557 hasAuthorship W4285138557A5007979807 @default.
- W4285138557 hasAuthorship W4285138557A5019654932 @default.
- W4285138557 hasAuthorship W4285138557A5021687717 @default.
- W4285138557 hasAuthorship W4285138557A5026825966 @default.
- W4285138557 hasAuthorship W4285138557A5050238370 @default.
- W4285138557 hasAuthorship W4285138557A5057891766 @default.
- W4285138557 hasAuthorship W4285138557A5060883903 @default.
- W4285138557 hasAuthorship W4285138557A5062451757 @default.
- W4285138557 hasAuthorship W4285138557A5063213559 @default.
- W4285138557 hasAuthorship W4285138557A5072861783 @default.
- W4285138557 hasBestOaLocation W42851385571 @default.
- W4285138557 hasConcept C11988809 @default.
- W4285138557 hasConcept C126322002 @default.
- W4285138557 hasConcept C197934379 @default.
- W4285138557 hasConcept C2777178219 @default.
- W4285138557 hasConcept C2778319317 @default.
- W4285138557 hasConcept C2778690821 @default.
- W4285138557 hasConcept C2779134260 @default.
- W4285138557 hasConcept C2780850621 @default.
- W4285138557 hasConcept C3008058167 @default.
- W4285138557 hasConcept C524204448 @default.
- W4285138557 hasConcept C71924100 @default.
- W4285138557 hasConcept C90924648 @default.
- W4285138557 hasConceptScore W4285138557C11988809 @default.
- W4285138557 hasConceptScore W4285138557C126322002 @default.
- W4285138557 hasConceptScore W4285138557C197934379 @default.
- W4285138557 hasConceptScore W4285138557C2777178219 @default.
- W4285138557 hasConceptScore W4285138557C2778319317 @default.
- W4285138557 hasConceptScore W4285138557C2778690821 @default.
- W4285138557 hasConceptScore W4285138557C2779134260 @default.
- W4285138557 hasConceptScore W4285138557C2780850621 @default.
- W4285138557 hasConceptScore W4285138557C3008058167 @default.
- W4285138557 hasConceptScore W4285138557C524204448 @default.
- W4285138557 hasConceptScore W4285138557C71924100 @default.
- W4285138557 hasConceptScore W4285138557C90924648 @default.
- W4285138557 hasIssue "1" @default.
- W4285138557 hasLocation W42851385571 @default.
- W4285138557 hasOpenAccess W4285138557 @default.
- W4285138557 hasPrimaryLocation W42851385571 @default.
- W4285138557 hasRelatedWork W2151082410 @default.
- W4285138557 hasRelatedWork W3026277345 @default.
- W4285138557 hasRelatedWork W3092879025 @default.
- W4285138557 hasRelatedWork W3132427123 @default.
- W4285138557 hasRelatedWork W3168330114 @default.
- W4285138557 hasRelatedWork W4205993479 @default.
- W4285138557 hasRelatedWork W4285795734 @default.
- W4285138557 hasRelatedWork W4289262226 @default.
- W4285138557 hasRelatedWork W4386867062 @default.
- W4285138557 hasRelatedWork W3214604417 @default.
- W4285138557 hasVolume "9" @default.
- W4285138557 isParatext "false" @default.
- W4285138557 isRetracted "false" @default.
- W4285138557 workType "article" @default.