Matches in SemOpenAlex for { <https://semopenalex.org/work/W4285138974> ?p ?o ?g. }
Showing items 1 to 84 of
84
with 100 items per page.
- W4285138974 endingPage "35" @default.
- W4285138974 startingPage "28" @default.
- W4285138974 abstract "Beyond their seminal role in hemostasis and thrombosis, platelets (PLTs) are now acknowledged as having multiple roles in the host's defense against infection. PLTs are proven to exert antimicrobial functions<i> in vitro</i>, <i>ex vivo</i>, and <i>in vivo</i>. However, different species of bacteria interact with PLTs differentially. Data concerning the interaction between PLTs and <i>Staphylococcus epidermidis</i> (<i>S. epidermidis</i>), the major prevalent species of nosocomial pathogens, and their related mechanisms are limited. In this study, the direct effects of PLTs on the metabolism and proliferation of <i>S. epidermidis</i> were evaluated. The PLTs from peripheral blood were purified and washed. The PLTs were found to significantly inhibit the proliferation of <i>S. epidermidis</i> when they were cocultured <i>in vitro</i>. Moreover, qRT-PCR showed that the expression of G6PD of the bacteria, a key enzyme in the pentose phosphate pathway, had been down-regulated signally. When the products (GDL, IMP) of the phosphate pentose pathway (PPP) were added to the culture, the antibacterial effect of PLTs was alleviated. This study suggests that PLTs can directly inhibit the proliferation of <i>S. epidermidis</i> and regulate their glucose metabolism, which may play an important role in their direct antimicrobial functions." @default.
- W4285138974 created "2022-07-14" @default.
- W4285138974 creator A5010670798 @default.
- W4285138974 creator A5019636853 @default.
- W4285138974 creator A5025552633 @default.
- W4285138974 creator A5039145306 @default.
- W4285138974 creator A5049386904 @default.
- W4285138974 creator A5072550199 @default.
- W4285138974 creator A5081635779 @default.
- W4285138974 creator A5085298167 @default.
- W4285138974 creator A5089268577 @default.
- W4285138974 date "2022-01-01" @default.
- W4285138974 modified "2023-09-27" @default.
- W4285138974 title "Platelets inhibit the proliferation of <i>Staphylococcus epidermidis</i> by directly down-regulating <i>G6PD</i>" @default.
- W4285138974 doi "https://doi.org/10.46701/bg.2022012021131" @default.
- W4285138974 hasPublicationYear "2022" @default.
- W4285138974 type Work @default.
- W4285138974 citedByCount "1" @default.
- W4285138974 countsByYear W42851389742022 @default.
- W4285138974 crossrefType "journal-article" @default.
- W4285138974 hasAuthorship W4285138974A5010670798 @default.
- W4285138974 hasAuthorship W4285138974A5019636853 @default.
- W4285138974 hasAuthorship W4285138974A5025552633 @default.
- W4285138974 hasAuthorship W4285138974A5039145306 @default.
- W4285138974 hasAuthorship W4285138974A5049386904 @default.
- W4285138974 hasAuthorship W4285138974A5072550199 @default.
- W4285138974 hasAuthorship W4285138974A5081635779 @default.
- W4285138974 hasAuthorship W4285138974A5085298167 @default.
- W4285138974 hasAuthorship W4285138974A5089268577 @default.
- W4285138974 hasBestOaLocation W42851389741 @default.
- W4285138974 hasConcept C181199279 @default.
- W4285138974 hasConcept C185592680 @default.
- W4285138974 hasConcept C20251656 @default.
- W4285138974 hasConcept C202751555 @default.
- W4285138974 hasConcept C203014093 @default.
- W4285138974 hasConcept C207001950 @default.
- W4285138974 hasConcept C26291073 @default.
- W4285138974 hasConcept C2777949923 @default.
- W4285138974 hasConcept C2779489039 @default.
- W4285138974 hasConcept C3409486 @default.
- W4285138974 hasConcept C4937899 @default.
- W4285138974 hasConcept C523546767 @default.
- W4285138974 hasConcept C54355233 @default.
- W4285138974 hasConcept C55493867 @default.
- W4285138974 hasConcept C86803240 @default.
- W4285138974 hasConcept C89423630 @default.
- W4285138974 hasConcept C89560881 @default.
- W4285138974 hasConceptScore W4285138974C181199279 @default.
- W4285138974 hasConceptScore W4285138974C185592680 @default.
- W4285138974 hasConceptScore W4285138974C20251656 @default.
- W4285138974 hasConceptScore W4285138974C202751555 @default.
- W4285138974 hasConceptScore W4285138974C203014093 @default.
- W4285138974 hasConceptScore W4285138974C207001950 @default.
- W4285138974 hasConceptScore W4285138974C26291073 @default.
- W4285138974 hasConceptScore W4285138974C2777949923 @default.
- W4285138974 hasConceptScore W4285138974C2779489039 @default.
- W4285138974 hasConceptScore W4285138974C3409486 @default.
- W4285138974 hasConceptScore W4285138974C4937899 @default.
- W4285138974 hasConceptScore W4285138974C523546767 @default.
- W4285138974 hasConceptScore W4285138974C54355233 @default.
- W4285138974 hasConceptScore W4285138974C55493867 @default.
- W4285138974 hasConceptScore W4285138974C86803240 @default.
- W4285138974 hasConceptScore W4285138974C89423630 @default.
- W4285138974 hasConceptScore W4285138974C89560881 @default.
- W4285138974 hasIssue "1" @default.
- W4285138974 hasLocation W42851389741 @default.
- W4285138974 hasOpenAccess W4285138974 @default.
- W4285138974 hasPrimaryLocation W42851389741 @default.
- W4285138974 hasRelatedWork W1489645645 @default.
- W4285138974 hasRelatedWork W1981376286 @default.
- W4285138974 hasRelatedWork W2090646249 @default.
- W4285138974 hasRelatedWork W2137142097 @default.
- W4285138974 hasRelatedWork W2351625518 @default.
- W4285138974 hasRelatedWork W2431007131 @default.
- W4285138974 hasRelatedWork W2753184995 @default.
- W4285138974 hasRelatedWork W2954159082 @default.
- W4285138974 hasRelatedWork W2978793169 @default.
- W4285138974 hasRelatedWork W2894777053 @default.
- W4285138974 hasVolume "6" @default.
- W4285138974 isParatext "false" @default.
- W4285138974 isRetracted "false" @default.
- W4285138974 workType "article" @default.