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- W4285139208 abstract "Glycogen synthase kinase-3 (GSK-3), initially identified as constitutively active and dynamic Ser/Thr kinase, exerts its influence on many cellular processes, including glycogen metabolism, apoptosis, and embryogenesis. Aberrant GSK-3 expression causes adverse pathologies, including type 2 diabetes, inflammation, neurodegeneration, and cancer. GSK-3 targets multiple signaling pathways impeding neuronal development, neurogenesis, and augments proinflammatory responses. The plausible role of GSK-3 in several biological processes has prompted efforts for GSK-3 inhibitor design and development. Inhibition of GSK-3 via potent inhibitors has become an attractive strategy for combating neurodegenerative and psychiatric disorders. The pharmacological GSK-3 inhibitors are majorly derived from natural or synthetic sources. Here, we provide state-of-the-art the pliable functions of multitasking GSK-3 in neurodegenerative etiologies. We further highlight the recent developments of GSK-3 inhibitors, their mechanistic insights, therapeutic potency, and clinical implications in central nervous system (CNS) disorders. Furthermore, the future challenges associated with the applicability of GSK-3 inhibitors have also been discussed." @default.
- W4285139208 created "2022-07-14" @default.
- W4285139208 creator A5019943988 @default.
- W4285139208 creator A5021941753 @default.
- W4285139208 creator A5033293921 @default.
- W4285139208 date "2022-01-01" @default.
- W4285139208 modified "2023-10-16" @default.
- W4285139208 title "Therapeutic targeting of glycogen synthase kinase-3: Strategy to address neurodegenerative diseases" @default.
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