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- W4285139839 abstract "High altitude sickness is associated with increased levels of reactive oxygen species (ROS) that leads to oxidative stress in cells. At elevated mountains, hypoxia induces several signaling pathways that contribute to imbalance in cellular homeostasis and oxidative stress. This can further lead to altered redox balance and accumulation of free radicals resulting in numerous pathophysiological disorders including pulmonary asthma, cardiovascular and metabolic disorders. Balanced ratio of pro- and antioxidants is essential for healthy life. Thus, antioxidant supplements are usually given at high altitudes to maintain cellular homeostasis. Use of antioxidant supplements can strengthen the surpassed levels of ROS in respond to oxidative stress and the supply of antioxidants is enhanced by using nanotechnology. The recent advancement in nanotechnology has ensued sustained delivery of drugs and more efficient results in curing various metabolic disorders. Emergence of nanotechnology has provided researchers with enhanced solubility, bioavailability, stability with less toxicity and conventional side effects. This chapter highlights the relation amid high altitudes, increased oxidative stress, and how antioxidant supplements and nanomaterial conjugated antioxidants provide shield to cells and ameliorates the oxidative damage in high altitude related sickness." @default.
- W4285139839 created "2022-07-14" @default.
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- W4285139839 date "2022-01-01" @default.
- W4285139839 modified "2023-09-26" @default.
- W4285139839 title "Antioxidant Therapy for High Altitude Sickness and Nano-Medicine" @default.
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- W4285139839 doi "https://doi.org/10.1007/978-981-19-1008-1_13" @default.
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