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- W4285149507 abstract "Increased interest in RNA and its dynamic regulation has led to the development of a new class of therapeutic agents, collectively named RNA therapeutics, with the two most advanced classes developed to date being antisense oligonucleotides and small interfering RNAs. The potential of oligonucleotide-based therapies to enter the cells, their high specificity, and the development of carriers that enable their tissue-specific delivery have quickly introduced RNA-based therapies into the clinic. The cardiovascular field is one of the first to experience the tremendous potential of RNA-based therapeutics with the introduction of multiple RNA therapies targeting components of the lipid metabolism such as proprotein convertase subtilisin/kexin type 9 (PCSK9), lipoprotein(a) or apolipoprotein C-III, as well as transthyretin. Future therapies targeting novel disease-relevant mRNA or pleiotropic regulatory noncoding RNAs are underway, projected to constitute central players in the era of precision medicine." @default.
- W4285149507 created "2022-07-14" @default.
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- W4285149507 date "2022-01-01" @default.
- W4285149507 modified "2023-09-25" @default.
- W4285149507 title "RNA therapies for cardiovascular disease" @default.
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- W4285149507 doi "https://doi.org/10.1016/b978-0-12-822546-2.00003-4" @default.
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