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- W4285154976 abstract "Metabolic endotoxemia (ME) refers to a condition in which endotoxin levels (lipopolysaccharide) are significantly elevated in the blood, without the evidence of an infection. ME may activate toll-like receptor 4 (TLR-4) mediated inflammatory reactions and enhance a low-grade chronic inflammatory and oxidative stress resulting in damage of target organs. ME plays an important role in the pathophysiology of different chronic inflammatory diseases especially cardiovascular disorders (obesity, type 2 diabetes mellitus), non-alcoholic fatty liver disease (NAFLD), pancreatitis, and brain diseases including Alzheimer’s disease. Various studies reported that gut biota alteration leads to leakage in intestinal membrane which results in translocation of microbial components (endotoxin) in systemic circulation and escalate pro-inflammatory cytokines. Thus manipulation of gut microbiota can prove to be an important strategy to treat ME. Probiotics are alive microorganisms which, when administered in sufficient amounts, shows favorable effects during gut dysbiosis. Prebiotics are dietary fibers that increase the count of beneficial bacteria via selectively stimulation of their growth and nourishment while decrease the count of pathogenic bacteria that release endotoxins. This chapter will enlighten upon possible mechanisms via which gut dysbiosis leads to metabolic endotoxemia and role of probiotic/prebiotic supplementation in metabolic endotoxemia." @default.
- W4285154976 created "2022-07-14" @default.
- W4285154976 creator A5035889335 @default.
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- W4285154976 date "2022-01-01" @default.
- W4285154976 modified "2023-10-17" @default.
- W4285154976 title "Effect of Pre/Probiotic Supplementation on Metabolic Endotoxemia" @default.
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- W4285154976 doi "https://doi.org/10.1007/978-981-16-8444-9_3" @default.
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