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- W4285155551 endingPage "214" @default.
- W4285155551 startingPage "163" @default.
- W4285155551 abstract "Plasma protein binding and tissue binding are arguably two of the most critical parameters that are measured as part of a drug discovery program since, according to the free drug hypothesis, it is the free drug that is responsible for both efficacy and toxicity. This chapter aims to deconstruct the role of plasma protein and tissue binding in drug discovery programs, and to consider the conclusion made by Pfizer and Genentech/Depomed a decade ago that optimising plasma protein binding as an independent parameter does not significantly influence efficacy. This chapter will also examine how binding metrics are applied in drug discovery programs and explore circumstances where optimising plasma protein or tissue binding can be an effective strategy to deliver a candidate molecule for preclinical development with an early indication of sufficient therapeutic index." @default.
- W4285155551 created "2022-07-14" @default.
- W4285155551 creator A5063506272 @default.
- W4285155551 creator A5068177646 @default.
- W4285155551 creator A5077211945 @default.
- W4285155551 creator A5088189318 @default.
- W4285155551 date "2022-01-01" @default.
- W4285155551 modified "2023-09-30" @default.
- W4285155551 title "The importance of plasma protein and tissue binding in a drug discovery program to successfully deliver a preclinical candidate" @default.
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