FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4285156922> ?p ?o ?g. }

• W4285156922 abstract "Dexmedetomidine (DEX) is known to provide neuroprotection against cerebral ischemia and reperfusion injury (CIRI), but the exact mechanisms remain unclear. This study was conducted to investigate whether DEX pretreatment conferred neuroprotection against CIRI by inhibiting neuroinflammation through the JAK2/STAT3 signaling pathway. Middle cerebral artery occlusion (MCAO) was performed to establish a cerebral ischemia/reperfusion (I/R) model. Specific-pathogen-free male Sprague-Dawley rats were randomly divided into Sham, I/R, DEX, DEX+IL-6, and AG490 (a selective inhibitor of JAK2) groups. The Longa score, TTC staining, and HE staining were used to evaluate brain damage. ELISA was used to exam levels of TNF-α. Western blotting was used to assess the levels of JAK2, phosphorylated-JAK2 (p-JAK2), STAT3, and phosphorylated-STAT3 (p-STAT3). Our results suggested that both pretreatment with DEX and AG490 decreased the Longa score and cerebral infarct areas following cerebral I/R. After treatment with IL-6, the effects of DEX on abrogating these pathological changes were reduced. HE staining revealed that I/R-induced neuronal pathological changes were attenuated by DEX application, consistent with the AG490 group. However, these effects of DEX were abolished by IL-6. Furthermore, TNF-α levels were significantly increased in the I/R group, accompanied by an increase in the levels of the p-JAK2 and p-STAT3. DEX and AG490 pretreatment down-regulated the expressions of TNF-α, p-JAK2, and p-STAT3. In contrast, the down-regulation of TNF-α, p-JAK2, and p-STAT3 induced by DEX was reversed by IL-6. Collectively, our results indicated that DEX pretreatment conferred neuroprotection against CIRI by inhibiting neuroinflammation via negatively regulating the JAK2/STAT3 signaling pathway." @default.
• W4285156922 created "2022-07-14" @default.
• W4285156922 creator A5010013200 @default.
• W4285156922 creator A5038860664 @default.
• W4285156922 creator A5039041442 @default.
• W4285156922 creator A5052111392 @default.
• W4285156922 creator A5065564517 @default.
• W4285156922 creator A5071702265 @default.
• W4285156922 date "2022-01-01" @default.
• W4285156922 modified "2023-10-02" @default.
• W4285156922 title "Dexmedetomidine pretreatment alleviates cerebral ischemia/reperfusion injury by inhibiting neuroinflammation through the JAK2/STAT3 pathway" @default.
• W4285156922 cites W2040736784 @default.
• W4285156922 cites W2062957986 @default.
• W4285156922 cites W2101674165 @default.
• W4285156922 cites W2112505121 @default.
• W4285156922 cites W2159117338 @default.
• W4285156922 cites W2516507980 @default.
• W4285156922 cites W2563101912 @default.
• W4285156922 cites W2604303367 @default.
• W4285156922 cites W2756718435 @default.
• W4285156922 cites W2803958951 @default.
• W4285156922 cites W2808970126 @default.
• W4285156922 cites W2887138446 @default.
• W4285156922 cites W2892635078 @default.
• W4285156922 cites W2949642899 @default.
• W4285156922 cites W2950741708 @default.
• W4285156922 cites W2979256511 @default.
• W4285156922 cites W2982345079 @default.
• W4285156922 cites W2999070109 @default.
• W4285156922 cites W3015094544 @default.
• W4285156922 cites W3081992244 @default.
• W4285156922 cites W3090733287 @default.
• W4285156922 cites W3141883903 @default.
• W4285156922 cites W3171272048 @default.
• W4285156922 cites W3172917004 @default.
• W4285156922 cites W3199563167 @default.
• W4285156922 cites W3201248636 @default.
• W4285156922 cites W3202218306 @default.
• W4285156922 cites W3203008425 @default.
• W4285156922 cites W3208933594 @default.
• W4285156922 cites W3211661073 @default.
• W4285156922 doi "https://doi.org/10.1590/1414-431x2022e12145" @default.
• W4285156922 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/35858000" @default.
• W4285156922 hasPublicationYear "2022" @default.
• W4285156922 type Work @default.
• W4285156922 citedByCount "6" @default.
• W4285156922 countsByYear W42851569222022 @default.
• W4285156922 countsByYear W42851569222023 @default.
• W4285156922 crossrefType "journal-article" @default.
• W4285156922 hasAuthorship W4285156922A5010013200 @default.
• W4285156922 hasAuthorship W4285156922A5038860664 @default.
• W4285156922 hasAuthorship W4285156922A5039041442 @default.
• W4285156922 hasAuthorship W4285156922A5052111392 @default.
• W4285156922 hasAuthorship W4285156922A5065564517 @default.
• W4285156922 hasAuthorship W4285156922A5071702265 @default.
• W4285156922 hasBestOaLocation W42851569222 @default.
• W4285156922 hasConcept C11960822 @default.
• W4285156922 hasConcept C126322002 @default.
• W4285156922 hasConcept C134018914 @default.
• W4285156922 hasConcept C185592680 @default.
• W4285156922 hasConcept C25498285 @default.
• W4285156922 hasConcept C2776914184 @default.
• W4285156922 hasConcept C2778923194 @default.
• W4285156922 hasConcept C2780114680 @default.
• W4285156922 hasConcept C42219234 @default.
• W4285156922 hasConcept C541997718 @default.
• W4285156922 hasConcept C55493867 @default.
• W4285156922 hasConcept C71924100 @default.
• W4285156922 hasConcept C87753298 @default.
• W4285156922 hasConcept C98274493 @default.
• W4285156922 hasConceptScore W4285156922C11960822 @default.
• W4285156922 hasConceptScore W4285156922C126322002 @default.
• W4285156922 hasConceptScore W4285156922C134018914 @default.
• W4285156922 hasConceptScore W4285156922C185592680 @default.
• W4285156922 hasConceptScore W4285156922C25498285 @default.
• W4285156922 hasConceptScore W4285156922C2776914184 @default.
• W4285156922 hasConceptScore W4285156922C2778923194 @default.
• W4285156922 hasConceptScore W4285156922C2780114680 @default.
• W4285156922 hasConceptScore W4285156922C42219234 @default.
• W4285156922 hasConceptScore W4285156922C541997718 @default.
• W4285156922 hasConceptScore W4285156922C55493867 @default.
• W4285156922 hasConceptScore W4285156922C71924100 @default.
• W4285156922 hasConceptScore W4285156922C87753298 @default.
• W4285156922 hasConceptScore W4285156922C98274493 @default.
• W4285156922 hasLocation W42851569221 @default.
• W4285156922 hasLocation W42851569222 @default.
• W4285156922 hasLocation W42851569223 @default.
• W4285156922 hasLocation W42851569224 @default.
• W4285156922 hasOpenAccess W4285156922 @default.
• W4285156922 hasPrimaryLocation W42851569221 @default.
• W4285156922 hasRelatedWork W2006800517 @default.
• W4285156922 hasRelatedWork W2252574504 @default.
• W4285156922 hasRelatedWork W2264866682 @default.
• W4285156922 hasRelatedWork W2361943286 @default.
• W4285156922 hasRelatedWork W2572779631 @default.
• W4285156922 hasRelatedWork W2789293914 @default.
• W4285156922 hasRelatedWork W2800277573 @default.
• W4285156922 hasRelatedWork W2889019399 @default.
• W4285156922 hasRelatedWork W2917855592 @default.
• W4285156922 hasRelatedWork W3147238946 @default.

• next