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• W4285158936 abstract "Cardiovascular diseases are major contributors to global deaths and disability-adjusted life years, with hypertension as a significant risk factor for all cause death. The endothelium that lines the inner wall of the vasculature regulates essential hemostatic functions such as regulation of the vascular tone, circulation of blood cells, inflammation, and platelet activity. Endothelial dysfunction is an early biomarker for subclinical atherosclerosis and can also be considered as a predictor for future cardiovascular events. We review the mechanisms leading to endothelial dysfunction with focus on oxidative stress, the clinical techniques for its determination, the prognostic value of measurements of endothelial function, as well as therapeutic approaches to treat endothelial dysfunction. Since vascular oxidative stress and inflammation are major determinants of endothelial function, we also address current antioxidant and antiinflammatory therapies. In light of recent data that argue against the prognostic value of endothelial function in healthy human cohorts, we also discuss alternative diagnostic parameters such as vascular stiffness index and intima/media thickness ratio. We also suggest that investigation of vascular function, including that of the smooth muscle and even perivascular adipose tissue, may be appropriate parameters for clinical investigations." @default.
• W4285158936 created "2022-07-14" @default.
• W4285158936 creator A5035254382 @default.
• W4285158936 creator A5039361810 @default.
• W4285158936 creator A5075027918 @default.
• W4285158936 date "2022-01-01" @default.
• W4285158936 modified "2023-09-29" @default.
• W4285158936 title "Endothelial dysfunction: basis for many local and systemic conditions" @default.
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