FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4285161036> ?p ?o ?g. }

• W4285161036 endingPage "446" @default.
• W4285161036 startingPage "439" @default.
• W4285161036 abstract "Celiac disease (CD) is an immune-dependent systemic disorder that occurs in genetically predisposed individuals resulting in damage in the small intestine. It is known that chromatin remodeling, an epigenetic mechanism, is associated with gastrointestinal diseases associated with chronic inflammation. However, no information is available on the link between CD and chromatin remodeling. For this purpose, the expression profiles of chromatin remodeling group genes in children diagnosed with CD according to Marsh classification and HLA profile were evaluated and their relationship with CD was investigated. Endoscopic biopsies embedded in the paraffin block of 40 children with CD diagnosis and 30 healthy children were included in the study. The most common four mutations (DQA1*05, DQB1*02, DQA1*03, and DQB1*03:02) related to CD on human leukocyte antigen (HLA) gene were screened. Intestinal biopsy samples were used for mRNA isolations and cDNA synthesis. Expressions of total seven genes in the chromatin remodeling groups (SWI/SNF Complex Group: ARID1A, Polycomb Group: CTBP1, Nucleosome-Remodeling & Histone Deacetylase (NuRD) Complex Group: MTA1, Chromobox/Heterochromatin Protein 1 (HP1) Homologs Group: CBX3 and CBX7, Homeodomain (PHD) Protein Group: NSD1, Inhibitor of Growth (ING) family group: ING 5) were analyzed by Real-Time qPCR. Data analysis was performed online using the software provided by the manufacturer. Overexpression in ARID1A, CTBP1, and NSD1 genes was detected when the CD group was compared against the control group, however they were not significant (p=0.31, 0.33, and 0.33). When CD group who had diarrhea symptom (typical) were compared to the CD group without diarrhea symptom (atypical), statistically significant under-expression was found in CBX3 and CTBP1 genes (p=0.04 and p=0.004). Statistically significant CTB1 overexpression was detected in Marsh 2 CD cases (p=0.03). In the comparison of HLA DQ2/DQ8 positive CD patient group with the control group, the NSD1, CBX3, and EED (p=0.75, 0.75, and 0.78) genes were over-expressed and the CBX7, MTA1, ARID1A, and CTBP1 genes (p=0.74, 0.75, 0.75, and 0.75) were under-expressed. This is the first study to report that expression of chromatin remodeling genes may have roles in the development and progression of CD. The results of this case-control study are open to confirmation by future studies with larger number of subjects to obtain statistically significant results." @default.
• W4285161036 created "2022-07-14" @default.
• W4285161036 creator A5028794954 @default.
• W4285161036 creator A5044579940 @default.
• W4285161036 creator A5062999394 @default.
• W4285161036 date "2022-01-01" @default.
• W4285161036 modified "2023-09-26" @default.
• W4285161036 title "Relationship between pediatric celiac disease and chromatin remodeling gene expressions" @default.
• W4285161036 cites W1967778417 @default.
• W4285161036 cites W2046366896 @default.
• W4285161036 cites W2062253609 @default.
• W4285161036 cites W2069534101 @default.
• W4285161036 cites W2076564588 @default.
• W4285161036 cites W2100548379 @default.
• W4285161036 cites W2118554097 @default.
• W4285161036 cites W2126824096 @default.
• W4285161036 cites W2141991853 @default.
• W4285161036 cites W2156101468 @default.
• W4285161036 cites W2288611291 @default.
• W4285161036 cites W2470967025 @default.
• W4285161036 cites W2891208572 @default.
• W4285161036 cites W2893627914 @default.
• W4285161036 cites W4237305910 @default.
• W4285161036 doi "https://doi.org/10.2298/gensr2201439b" @default.
• W4285161036 hasPublicationYear "2022" @default.
• W4285161036 type Work @default.
• W4285161036 citedByCount "1" @default.
• W4285161036 countsByYear W42851610362023 @default.
• W4285161036 crossrefType "journal-article" @default.
• W4285161036 hasAuthorship W4285161036A5028794954 @default.
• W4285161036 hasAuthorship W4285161036A5044579940 @default.
• W4285161036 hasAuthorship W4285161036A5062999394 @default.
• W4285161036 hasBestOaLocation W42851610361 @default.
• W4285161036 hasConcept C103435993 @default.
• W4285161036 hasConcept C104317684 @default.
• W4285161036 hasConcept C153911025 @default.
• W4285161036 hasConcept C161223559 @default.
• W4285161036 hasConcept C167227067 @default.
• W4285161036 hasConcept C179138559 @default.
• W4285161036 hasConcept C2781273526 @default.
• W4285161036 hasConcept C41091548 @default.
• W4285161036 hasConcept C501734568 @default.
• W4285161036 hasConcept C54355233 @default.
• W4285161036 hasConcept C64927066 @default.
• W4285161036 hasConcept C67705224 @default.
• W4285161036 hasConcept C83640560 @default.
• W4285161036 hasConcept C86803240 @default.
• W4285161036 hasConcept C92149661 @default.
• W4285161036 hasConceptScore W4285161036C103435993 @default.
• W4285161036 hasConceptScore W4285161036C104317684 @default.
• W4285161036 hasConceptScore W4285161036C153911025 @default.
• W4285161036 hasConceptScore W4285161036C161223559 @default.
• W4285161036 hasConceptScore W4285161036C167227067 @default.
• W4285161036 hasConceptScore W4285161036C179138559 @default.
• W4285161036 hasConceptScore W4285161036C2781273526 @default.
• W4285161036 hasConceptScore W4285161036C41091548 @default.
• W4285161036 hasConceptScore W4285161036C501734568 @default.
• W4285161036 hasConceptScore W4285161036C54355233 @default.
• W4285161036 hasConceptScore W4285161036C64927066 @default.
• W4285161036 hasConceptScore W4285161036C67705224 @default.
• W4285161036 hasConceptScore W4285161036C83640560 @default.
• W4285161036 hasConceptScore W4285161036C86803240 @default.
• W4285161036 hasConceptScore W4285161036C92149661 @default.
• W4285161036 hasIssue "1" @default.
• W4285161036 hasLocation W42851610361 @default.
• W4285161036 hasOpenAccess W4285161036 @default.
• W4285161036 hasPrimaryLocation W42851610361 @default.
• W4285161036 hasRelatedWork W1588926062 @default.
• W4285161036 hasRelatedWork W168279297 @default.
• W4285161036 hasRelatedWork W2060237924 @default.
• W4285161036 hasRelatedWork W2126094650 @default.
• W4285161036 hasRelatedWork W2141028091 @default.
• W4285161036 hasRelatedWork W2338344824 @default.
• W4285161036 hasRelatedWork W2743033273 @default.
• W4285161036 hasRelatedWork W3037857843 @default.
• W4285161036 hasRelatedWork W3048230532 @default.
• W4285161036 hasRelatedWork W2577225368 @default.
• W4285161036 hasVolume "54" @default.
• W4285161036 isParatext "false" @default.
• W4285161036 isRetracted "false" @default.
• W4285161036 workType "article" @default.