Matches in SemOpenAlex for { <https://semopenalex.org/work/W4285164848> ?p ?o ?g. }
- W4285164848 endingPage "117957352210925" @default.
- W4285164848 startingPage "117957352210925" @default.
- W4285164848 abstract "Huntington's disease (HD) is an autosomal neurodegenerative disease that is characterized by an excessive number of CAG trinucleotide repeats within the huntingtin gene (HTT). HD patients can present with a variety of symptoms including chorea, behavioural and psychiatric abnormalities and cognitive decline. Each patient has a unique combination of symptoms, and although these can be managed using a range of medications and non-drug treatments there is currently no cure for the disease. Current therapies prescribed for HD can be categorized by the symptom they treat. These categories include chorea medication, antipsychotic medication, antidepressants, mood stabilizing medication as well as non-drug therapies. Fortunately, there are also many new HD therapeutics currently undergoing clinical trials that target the disease at its origin; lowering the levels of mutant huntingtin protein (mHTT). Currently, much attention is being directed to antisense oligonucleotide (ASO) therapies, which bind to pre-RNA or mRNA and can alter protein expression via RNA degradation, blocking translation or splice modulation. Other potential therapies in clinical development include RNA interference (RNAi) therapies, RNA targeting small molecule therapies, stem cell therapies, antibody therapies, non-RNA targeting small molecule therapies and neuroinflammation targeted therapies. Potential therapies in pre-clinical development include Zinc-Finger Protein (ZFP) therapies, transcription activator-like effector nuclease (TALEN) therapies and clustered regularly interspaced short palindromic repeats (CRISPR)/CRISPR-associated system (Cas) therapies. This comprehensive review aims to discuss the efficacy of current HD treatments and explore the clinical trial progress of emerging potential HD therapeutics." @default.
- W4285164848 created "2022-07-14" @default.
- W4285164848 creator A5032388309 @default.
- W4285164848 creator A5063571066 @default.
- W4285164848 creator A5065002479 @default.
- W4285164848 creator A5081213685 @default.
- W4285164848 creator A5085058765 @default.
- W4285164848 creator A5085666861 @default.
- W4285164848 date "2022-01-01" @default.
- W4285164848 modified "2023-10-01" @default.
- W4285164848 title "Current and Possible Future Therapeutic Options for Huntington’s Disease" @default.
- W4285164848 cites W1156601377 @default.
- W4285164848 cites W1474537196 @default.
- W4285164848 cites W1489116022 @default.
- W4285164848 cites W1500857601 @default.
- W4285164848 cites W1507443798 @default.
- W4285164848 cites W1526327880 @default.
- W4285164848 cites W1535920245 @default.
- W4285164848 cites W153750880 @default.
- W4285164848 cites W1557552045 @default.
- W4285164848 cites W1564051520 @default.
- W4285164848 cites W1575362995 @default.
- W4285164848 cites W1579914164 @default.
- W4285164848 cites W1580995615 @default.
- W4285164848 cites W1606783190 @default.
- W4285164848 cites W166631983 @default.
- W4285164848 cites W1677086521 @default.
- W4285164848 cites W176535219 @default.
- W4285164848 cites W1769984785 @default.
- W4285164848 cites W182612897 @default.
- W4285164848 cites W1881287185 @default.
- W4285164848 cites W1904924604 @default.
- W4285164848 cites W1920418959 @default.
- W4285164848 cites W1925196301 @default.
- W4285164848 cites W1954411904 @default.
- W4285164848 cites W1954888178 @default.
- W4285164848 cites W1963849215 @default.
- W4285164848 cites W1965073347 @default.
- W4285164848 cites W1966815691 @default.
- W4285164848 cites W1967627236 @default.
- W4285164848 cites W1971643509 @default.
- W4285164848 cites W1974132683 @default.
- W4285164848 cites W1980658715 @default.
- W4285164848 cites W1984043350 @default.
- W4285164848 cites W1990192129 @default.
- W4285164848 cites W1991686179 @default.
- W4285164848 cites W1991964306 @default.
- W4285164848 cites W1993068285 @default.
- W4285164848 cites W1993978355 @default.
- W4285164848 cites W1994243055 @default.
- W4285164848 cites W1994285647 @default.
- W4285164848 cites W1995130178 @default.
- W4285164848 cites W1995321160 @default.
- W4285164848 cites W1995983179 @default.
- W4285164848 cites W1996942647 @default.
- W4285164848 cites W1997188614 @default.
- W4285164848 cites W1998482324 @default.
- W4285164848 cites W1998902830 @default.
- W4285164848 cites W1999081857 @default.
- W4285164848 cites W2000931238 @default.
- W4285164848 cites W2002082564 @default.
- W4285164848 cites W2002875429 @default.
- W4285164848 cites W2003927727 @default.
- W4285164848 cites W2005710138 @default.
- W4285164848 cites W2007719003 @default.
- W4285164848 cites W2008836145 @default.
- W4285164848 cites W2008979655 @default.
- W4285164848 cites W2009446131 @default.
- W4285164848 cites W2009801894 @default.
- W4285164848 cites W2011040201 @default.
- W4285164848 cites W2015214742 @default.
- W4285164848 cites W2015224507 @default.
- W4285164848 cites W2017774656 @default.
- W4285164848 cites W2019969295 @default.
- W4285164848 cites W2022774407 @default.
- W4285164848 cites W2022980568 @default.
- W4285164848 cites W2023627547 @default.
- W4285164848 cites W2024943800 @default.
- W4285164848 cites W2027367467 @default.
- W4285164848 cites W2027385910 @default.
- W4285164848 cites W2027812544 @default.
- W4285164848 cites W2027835288 @default.
- W4285164848 cites W2028349138 @default.
- W4285164848 cites W2032448955 @default.
- W4285164848 cites W2032884131 @default.
- W4285164848 cites W2038537185 @default.
- W4285164848 cites W2038763233 @default.
- W4285164848 cites W2039100312 @default.
- W4285164848 cites W2041983408 @default.
- W4285164848 cites W2042739691 @default.
- W4285164848 cites W2043743268 @default.
- W4285164848 cites W2043899474 @default.
- W4285164848 cites W2044562956 @default.
- W4285164848 cites W2046511192 @default.
- W4285164848 cites W2048323087 @default.
- W4285164848 cites W2048407382 @default.
- W4285164848 cites W2048817289 @default.
- W4285164848 cites W2050476079 @default.