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- W4285166380 endingPage "447" @default.
- W4285166380 startingPage "421" @default.
- W4285166380 abstract "Zebrafish as a pharmacological model is gaining popularity due to its similarity in both transcriptional and developmental physiology with humans. In this chapter, zebrafish as a relevant model for gastrointestinal tract (GIT) diseases including inflammatory bowel disease (IBD) and GIT cancers is outlined. Information on the relevance of zebrafish models in cancer metastasis, host-microbe interactions, and screening of new drugs is also included in this chapter. In IBD, zebrafish as a tool is used to understand both the pathogenesis and treatment outcomes such as immune suppression or disease regression through drug screening. TgBAC, a transgenic zebrafish line, has revealed two major factors which results into IBD including depletion of epigenetic repression as well as excessive production of tumor necrosis factor. The features of human IBD disease pathology are observed in chemically induced zebrafish models, which are well established and commonly used to test the new chemical entities (NCEs). In addition, zebrafish models are also used to understand IBD immunology including expression of chemokine responses which are difficult to investigate in murine models and to understand intestinal development and GIT transit. Factors such as high fertility, low maintenance, and physiological and developmental similarities in the GIT with humans make zebrafish an efficient model to explore GIT cancers. In addition, comparative genomics to humans, transparent body, and rapidly developing embryos are prominent factors for the successful use of zebrafish models in GIT cancers." @default.
- W4285166380 created "2022-07-14" @default.
- W4285166380 creator A5034116241 @default.
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- W4285166380 date "2022-01-01" @default.
- W4285166380 modified "2023-10-01" @default.
- W4285166380 title "Pharmacological Modeling of Gastrointestinal Disorders in Zebrafish for Drug Discovery and Development" @default.
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