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- W4285172324 abstract "Mitochondrial calcium (Ca2+) plays a key role in regulating normal cardiac function. A physiological increase in mitochondrial matrix calcium [Ca2+]m drives mitochondrial ATP production to meet the high-energy demands during excitation–contraction coupling. However, a pathological increase in [Ca2+]m leads to increased oxidative stress, impaired bioenergetics, and the opening of mitochondrial permeability transition pore (mPTP), a hallmark of the failing heart. Therefore, a better understanding of the [Ca2+]m handling and its role in heart function and dysfunction is of great importance. Here, we describe a detailed protocol for measuring mitochondrial Ca2+ handling in the isolated functionally intact mitochondria from cardiac tissue of the guinea pig." @default.
- W4285172324 created "2022-07-14" @default.
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- W4285172324 date "2022-01-01" @default.
- W4285172324 modified "2023-10-18" @default.
- W4285172324 title "Mitochondrial Calcium Handling in Isolated Mitochondria from a Guinea Pig Heart" @default.
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- W4285172324 doi "https://doi.org/10.1007/978-1-0716-2309-1_6" @default.
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