Matches in SemOpenAlex for { <https://semopenalex.org/work/W4285173671> ?p ?o ?g. }
- W4285173671 endingPage "4199" @default.
- W4285173671 startingPage "4181" @default.
- W4285173671 abstract "Background: The APOBEC (apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like) family-mediated mutagenesis is widespread in human cancers. However, our knowledge of the biological feature and clinical relevance of APOBECs and APOBEC mutagenesis in cancers remains limited. Methods: In this study, with a series of bioinformatic and statistical approaches, we performed a comprehensive analysis of multiple levels of data, including whole-exome sequencing (WES) and targeted next-generation sequencing (NGS), transcriptome (bulk RNA-seq and single-cell RNA-seq), immune signatures and immune checkpoint blockade (ICB) potential, patient survival and drug sensitivity, to reveal the distribution characteristics and clinical significance of APOBECs and APOBEC mutagenesis in pan-cancer especially bladder cancer (BLCA). Results: APOBEC mutagenesis dominates in the mutational patterns of BLCA. A higher enrichment score of APOBEC mutagenesis correlates with favorable prognosis, immune activation and potential ICB response in BLCA patients. APOBEC3A and 3B play a significant role in the malignant progression and cell differentiation within the tumor microenvironment. Furthermore, using machine learning approaches, a prognostic APOBEC mutagenesis-related model was established and validated in different BLCA cohorts. Conclusions: Our study illustrates the characterization of APOBECs and APOBEC mutagenesis in multiple cancer types and highlights its potential value as a promising biomarker for prognosis and immunotherapy in BLCA." @default.
- W4285173671 created "2022-07-14" @default.
- W4285173671 creator A5004143939 @default.
- W4285173671 creator A5004928583 @default.
- W4285173671 creator A5006822602 @default.
- W4285173671 creator A5007910885 @default.
- W4285173671 creator A5012670084 @default.
- W4285173671 creator A5018008882 @default.
- W4285173671 creator A5018617806 @default.
- W4285173671 creator A5039944570 @default.
- W4285173671 creator A5050705404 @default.
- W4285173671 creator A5054029804 @default.
- W4285173671 creator A5060189095 @default.
- W4285173671 creator A5060220713 @default.
- W4285173671 creator A5074904959 @default.
- W4285173671 creator A5078943566 @default.
- W4285173671 creator A5085694835 @default.
- W4285173671 creator A5089285560 @default.
- W4285173671 creator A5091473946 @default.
- W4285173671 date "2022-01-01" @default.
- W4285173671 modified "2023-10-18" @default.
- W4285173671 title "APOBEC-mediated mutagenesis is a favorable predictor of prognosis and immunotherapy for bladder cancer patients: evidence from pan-cancer analysis and multiple databases" @default.
- W4285173671 cites W1842792112 @default.
- W4285173671 cites W1985987855 @default.
- W4285173671 cites W2003665515 @default.
- W4285173671 cites W2008811015 @default.
- W4285173671 cites W2025363465 @default.
- W4285173671 cites W2026347115 @default.
- W4285173671 cites W2028433016 @default.
- W4285173671 cites W2033775272 @default.
- W4285173671 cites W2043398720 @default.
- W4285173671 cites W2059995794 @default.
- W4285173671 cites W2104153021 @default.
- W4285173671 cites W2107551331 @default.
- W4285173671 cites W2108068107 @default.
- W4285173671 cites W2114299743 @default.
- W4285173671 cites W2124614719 @default.
- W4285173671 cites W2127870217 @default.
- W4285173671 cites W2130410032 @default.
- W4285173671 cites W2130430382 @default.
- W4285173671 cites W2131178190 @default.
- W4285173671 cites W2152061559 @default.
- W4285173671 cites W2152883907 @default.
- W4285173671 cites W2159707944 @default.
- W4285173671 cites W2159987716 @default.
- W4285173671 cites W2214074259 @default.
- W4285173671 cites W2294990791 @default.
- W4285173671 cites W2410097241 @default.
- W4285173671 cites W2426844253 @default.
- W4285173671 cites W2527720111 @default.
- W4285173671 cites W2581231749 @default.
- W4285173671 cites W2593030814 @default.
- W4285173671 cites W2655262992 @default.
- W4285173671 cites W2744844702 @default.
- W4285173671 cites W2763670669 @default.
- W4285173671 cites W2785803176 @default.
- W4285173671 cites W2788431960 @default.
- W4285173671 cites W2799320595 @default.
- W4285173671 cites W2806236616 @default.
- W4285173671 cites W2888686874 @default.
- W4285173671 cites W2896872272 @default.
- W4285173671 cites W2898789672 @default.
- W4285173671 cites W2904444972 @default.
- W4285173671 cites W2909679049 @default.
- W4285173671 cites W2920329247 @default.
- W4285173671 cites W2949273159 @default.
- W4285173671 cites W3005770805 @default.
- W4285173671 cites W3006509366 @default.
- W4285173671 cites W3012630958 @default.
- W4285173671 cites W3021646013 @default.
- W4285173671 cites W3039445960 @default.
- W4285173671 cites W3049314860 @default.
- W4285173671 cites W3136653115 @default.
- W4285173671 cites W3137102918 @default.
- W4285173671 cites W3158928451 @default.
- W4285173671 cites W3182293965 @default.
- W4285173671 cites W3196396792 @default.
- W4285173671 cites W3200871715 @default.
- W4285173671 cites W3211426120 @default.
- W4285173671 cites W4200028151 @default.
- W4285173671 doi "https://doi.org/10.7150/thno.73235" @default.
- W4285173671 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/35673559" @default.
- W4285173671 hasPublicationYear "2022" @default.
- W4285173671 type Work @default.
- W4285173671 citedByCount "9" @default.
- W4285173671 countsByYear W42851736712022 @default.
- W4285173671 countsByYear W42851736712023 @default.
- W4285173671 crossrefType "journal-article" @default.
- W4285173671 hasAuthorship W4285173671A5004143939 @default.
- W4285173671 hasAuthorship W4285173671A5004928583 @default.
- W4285173671 hasAuthorship W4285173671A5006822602 @default.
- W4285173671 hasAuthorship W4285173671A5007910885 @default.
- W4285173671 hasAuthorship W4285173671A5012670084 @default.
- W4285173671 hasAuthorship W4285173671A5018008882 @default.
- W4285173671 hasAuthorship W4285173671A5018617806 @default.
- W4285173671 hasAuthorship W4285173671A5039944570 @default.
- W4285173671 hasAuthorship W4285173671A5050705404 @default.
- W4285173671 hasAuthorship W4285173671A5054029804 @default.