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- W4285174518 abstract "Chronic liver disease and cirrhosis are a major worldwide health problem and represent the 11th leading cause of death in the USA based on data from 1999 to 2018 [1]. There are many etiologies of chronic liver disease including hepatotoxic factors such as viral hepatitis B and C, alcohol, nonalcoholic fatty liver disease, hemochromatosis, and autoimmune hepatitis, as well as biliary factors (toxicities) such as primary sclerosing cholangitis and primary biliary cirrhosis. While liver biopsy is the standard of reference for diagnosis and monitoring of liver fibrosis, it is an invasive procedure associated with a non-negligible complication risk [2]. Bleeding occurs in ~1 of 500 liver biopsies, which may be severe in 1 of 2500 to 10,000 liver biopsies [3]. Additional important complications include sepsis, pneumothorax, and hemothorax. The reported mortality risk from liver biopsy is up to 0.3% [4]. Aside from complications, liver biopsy is not an accurate reference standard. Important limitations of liver biopsy include small sample size (~1/50,000 part of liver) resulting in sampling errors due to the heterogeneity of diffuse liver disease, and high intra- and inter-observer variability in interpretation [5–12]." @default.
- W4285174518 created "2022-07-14" @default.
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- W4285174518 date "2022-01-01" @default.
- W4285174518 modified "2023-09-29" @default.
- W4285174518 title "Magnetic Resonance Elastography (MRE) to Assess Hepatic Fibrosis" @default.
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- W4285174518 doi "https://doi.org/10.1007/978-981-19-0063-1_14" @default.
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