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- W4285182317 endingPage "41" @default.
- W4285182317 startingPage "15" @default.
- W4285182317 abstract "Cellular prion protein (PrPC) is a membrane bound protein that undergoes several post translational modifications. It can exert pleiotropic functions either in physiological and pathological conditions. The disease-causing isoform of the prion protein, called PrPSc, acts as corruptive seed able to establish a process of misfolding and aggregation of further PrPSc molecules. Therefore, PrPC acts as substrate for PrPSc formation and as receptor to convey neurotoxic functions typical of other prion-like proteins involved in several neurodegenerative conditions. PrPC is transported from the outer leaflet of the cellular membrane to the intracellular compartments through several endocytic pathways, including clathrin-dependent and independent mechanisms and interactions with different adaptor proteins. During prion infection, the pathological counterpart PrPSc, can be uptaken by the cells with mechanisms partially overlapping the ones of the physiological form, PrPC. The intercellular routing of both prion protein isoforms involves the release through vesicles and tunneling nanotubes. From the extracellular milieu, PrPC and PrPSc can be uptaken by adjacent cells, thus exerting physiological and pathological functions." @default.
- W4285182317 created "2022-07-14" @default.
- W4285182317 creator A5006285239 @default.
- W4285182317 creator A5030945799 @default.
- W4285182317 creator A5067787869 @default.
- W4285182317 date "2023-01-01" @default.
- W4285182317 modified "2023-10-16" @default.
- W4285182317 title "Prion receptors, prion internalization, intra- and inter-cellular transport" @default.
- W4285182317 cites W1183792589 @default.
- W4285182317 cites W1483315850 @default.
- W4285182317 cites W1518703223 @default.
- W4285182317 cites W1554709620 @default.
- W4285182317 cites W1556847368 @default.
- W4285182317 cites W1557724928 @default.
- W4285182317 cites W1567267284 @default.
- W4285182317 cites W1589194965 @default.
- W4285182317 cites W1704732331 @default.
- W4285182317 cites W1965005357 @default.
- W4285182317 cites W1967319099 @default.
- W4285182317 cites W1969758868 @default.
- W4285182317 cites W1970413727 @default.
- W4285182317 cites W1972161622 @default.
- W4285182317 cites W1973510262 @default.
- W4285182317 cites W1973758214 @default.
- W4285182317 cites W1975257262 @default.
- W4285182317 cites W1976767726 @default.
- W4285182317 cites W1976981405 @default.
- W4285182317 cites W1977691538 @default.
- W4285182317 cites W1978217169 @default.
- W4285182317 cites W1979856683 @default.
- W4285182317 cites W1982739808 @default.
- W4285182317 cites W1984872025 @default.
- W4285182317 cites W1985630952 @default.
- W4285182317 cites W1987566729 @default.
- W4285182317 cites W1990496336 @default.
- W4285182317 cites W1991424179 @default.
- W4285182317 cites W1991913846 @default.
- W4285182317 cites W1993222068 @default.
- W4285182317 cites W1993590148 @default.
- W4285182317 cites W1998038512 @default.
- W4285182317 cites W1998249059 @default.
- W4285182317 cites W2000036908 @default.
- W4285182317 cites W2001306764 @default.
- W4285182317 cites W2001323244 @default.
- W4285182317 cites W2003156002 @default.
- W4285182317 cites W2008046104 @default.
- W4285182317 cites W2010238780 @default.
- W4285182317 cites W2012222860 @default.
- W4285182317 cites W2013679718 @default.
- W4285182317 cites W2015047834 @default.
- W4285182317 cites W2015350567 @default.
- W4285182317 cites W2015774470 @default.
- W4285182317 cites W2021260035 @default.
- W4285182317 cites W2022392367 @default.
- W4285182317 cites W2022507499 @default.
- W4285182317 cites W2022607259 @default.
- W4285182317 cites W2022654779 @default.
- W4285182317 cites W2023351166 @default.
- W4285182317 cites W2024273854 @default.
- W4285182317 cites W2024954984 @default.
- W4285182317 cites W2025328816 @default.
- W4285182317 cites W2027022625 @default.
- W4285182317 cites W2028622306 @default.
- W4285182317 cites W2029428782 @default.
- W4285182317 cites W2030072508 @default.
- W4285182317 cites W2030167827 @default.
- W4285182317 cites W2032706649 @default.
- W4285182317 cites W2032860676 @default.
- W4285182317 cites W2034359525 @default.
- W4285182317 cites W2035353125 @default.
- W4285182317 cites W2041060250 @default.
- W4285182317 cites W2042978244 @default.
- W4285182317 cites W2043923768 @default.
- W4285182317 cites W2043943109 @default.
- W4285182317 cites W2046248816 @default.
- W4285182317 cites W2047690397 @default.
- W4285182317 cites W2053636966 @default.
- W4285182317 cites W2054088381 @default.
- W4285182317 cites W2055791162 @default.
- W4285182317 cites W2056439848 @default.
- W4285182317 cites W2056648569 @default.
- W4285182317 cites W2058200171 @default.
- W4285182317 cites W2058994860 @default.
- W4285182317 cites W2059570253 @default.
- W4285182317 cites W2062379645 @default.
- W4285182317 cites W2063880942 @default.
- W4285182317 cites W2071441527 @default.
- W4285182317 cites W2071609717 @default.
- W4285182317 cites W2073472657 @default.
- W4285182317 cites W2076146345 @default.
- W4285182317 cites W2076624195 @default.
- W4285182317 cites W2077120971 @default.
- W4285182317 cites W2077657292 @default.
- W4285182317 cites W2077814641 @default.
- W4285182317 cites W2079139843 @default.
- W4285182317 cites W2080514032 @default.
- W4285182317 cites W2084469782 @default.
- W4285182317 cites W2089215677 @default.