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- W4285183947 endingPage "178" @default.
- W4285183947 startingPage "153" @default.
- W4285183947 abstract "According to the Biopharmaceutical Classification System, the solubility and permeability of a drug are the key drivers of its development. Drugs belonging to Classes II and IV are poorly water soluble and often require their physical form to be manipulated to achieve adequate dissolution. The formation of crystalline nanoparticles or nanocrystals can improve solubility and permeability and ultimately bioavailability owing to the greater surface to volume ratio. Crystalline nanoparticles are a suitable delivery system for all commonly used routes of administration, such as oral, injectable, pulmonary, ocular, and topical applications. In addition, aqueous dispersions of nanoparticles can be processed into tablets, capsules, fast-melts, and lyophilized products for sterile product applications. The pharmacokinetic profiles of nanocrystals may vary from rapidly soluble in the blood to gradual dissolving, after which macrophage uptake and subsequent drug release prolong drug delivery while minimizing the peak height. For certain drug classes, this leads to improved safety, permits higher dosing, and improves efficacy. Nanocrystals can target drug molecules in specific regions through size manipulation and surface modification. This chapter focuses on nanocrystal-based formulations as liquid nanosuspensions and after downstream processing to solid dosage forms, developed as drug delivery systems for various routes of administration. The compilation of material summarizes the therapeutic applications of pharmaceutical nanocrystals, highlighting their universality as a formulation approach to poorly soluble drugs." @default.
- W4285183947 created "2022-07-14" @default.
- W4285183947 creator A5024171791 @default.
- W4285183947 creator A5026675928 @default.
- W4285183947 date "2022-01-01" @default.
- W4285183947 modified "2023-10-18" @default.
- W4285183947 title "Drug nanocrystals as drug delivery systems" @default.
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