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- W4285185625 abstract "Vascular endothelial growth factor receptor tyrosine kinase inhibitors (VEGFR-TKIs) are being widely and effectively used as anticancer drugs in patients with solid tumors. However, several clinical and basic investigations have now provided concrete evidence that most of the VEGFR-TKIs possess cardiotoxic effects, especially in patients with a history of cardiovascular conditions. Among the various proposed mechanisms, disruption of mitochondrial function is postulated to be one of the principal mechanisms of VEGFR-TKI-induced cardiotoxicity. In this chapter, we discuss several clinical studies that have highlighted the deleterious effects of various VEGFR-TKIs on cardiac physiology and functions. We also review the underlying mechanisms of cardiotoxicity associated with each TKI and the prospective cardioprotective agents." @default.
- W4285185625 created "2022-07-14" @default.
- W4285185625 creator A5010298708 @default.
- W4285185625 date "2022-01-01" @default.
- W4285185625 modified "2023-09-28" @default.
- W4285185625 title "Cardiotoxic effects of tyrosine kinase inhibitors directed against VEGFR" @default.
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- W4285185625 doi "https://doi.org/10.1016/b978-0-323-90461-2.00008-0" @default.
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