FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4285185629> ?p ?o ?g. }

• W4285185629 endingPage "4309" @default.
• W4285185629 startingPage "4288" @default.
• W4285185629 abstract "Grafted astroglia/astrocytes exhibit neuroprotective effects and improve functional recovery after injury to the central nervous system. This study sought to elucidate their ability to repair spinal cord lesions and the underlying mechanisms. Methods: Complete spinal transection, transplantation of astroglia generated from human ESC-derived neural progenitor cells (NPC-Astros) or Olig2-GFP knock-in progenitors (Olig2PC-Astros), and immunostaining were used to determine the survival of astroglia. CUBIC tissue-clearing, immunostaining, electromyography, and functional tests such as the Basso Mouse Scale score and gait analysis were applied to analyze the recovery of the lesion area, axon regeneration, synapse formation, and motor function. Sholl analysis, immunostaining, depletion of anti-inflammatory microglia, and western blotting were employed to explore the cellular and molecular mechanisms underlying spinal cord repair. Results: Grafted NPC- or Olig2PC-Astros survived in the lesion area and assisted wound healing by reducing scar formation and promoting regrowth of descending serotonergic axons and synapse reformation beyond the lesion area. These positive effects resulted in increased Basso Mouse Scale scores and improved hindlimb function as determined by electromyography and gait analysis. Activated microglia in the lesion area were shifted towards an anti-inflammatory phenotype after transplantation of NPC- or Olig2PC-Astros, and depletion of anti-inflammatory microglia reversed the observed improvements in the lesion area and axon regeneration. Transplantation of NPC- or Olig2PC-Astros elevated the expression of interleukin-4 and promoted the phenotypic shift of microglial via interleukin-4 downstream signaling. Conclusion: Our findings indicate that grafted human ESC-derived NPC- or Olig2PC-Astros promote recovery of the injured spinal cord by shifting microglia towards an anti-inflammatory state in the lesion area and activating interleukin-4 signaling." @default.
• W4285185629 created "2022-07-14" @default.
• W4285185629 creator A5001959448 @default.
• W4285185629 creator A5027048963 @default.
• W4285185629 creator A5032764121 @default.
• W4285185629 creator A5061469820 @default.
• W4285185629 creator A5088240691 @default.
• W4285185629 date "2022-01-01" @default.
• W4285185629 modified "2023-10-17" @default.
• W4285185629 title "Grafted human ESC-derived astroglia repair spinal cord injury via activation of host anti-inflammatory microglia in the lesion area" @default.
• W4285185629 cites W1514632242 @default.
• W4285185629 cites W1566153698 @default.
• W4285185629 cites W1957468634 @default.
• W4285185629 cites W1966287868 @default.
• W4285185629 cites W1969444386 @default.
• W4285185629 cites W1973439716 @default.
• W4285185629 cites W1975681168 @default.
• W4285185629 cites W1977213877 @default.
• W4285185629 cites W1983273439 @default.
• W4285185629 cites W1983325630 @default.
• W4285185629 cites W1990486050 @default.
• W4285185629 cites W2004756585 @default.
• W4285185629 cites W2009097826 @default.
• W4285185629 cites W2016010209 @default.
• W4285185629 cites W2019780808 @default.
• W4285185629 cites W2020655188 @default.
• W4285185629 cites W2037892763 @default.
• W4285185629 cites W2041571943 @default.
• W4285185629 cites W2056319562 @default.
• W4285185629 cites W2081176154 @default.
• W4285185629 cites W2085177202 @default.
• W4285185629 cites W2086773210 @default.
• W4285185629 cites W2106887160 @default.
• W4285185629 cites W2114860843 @default.
• W4285185629 cites W2116850178 @default.
• W4285185629 cites W2132301122 @default.
• W4285185629 cites W2156757115 @default.
• W4285185629 cites W2160249662 @default.
• W4285185629 cites W2169468294 @default.
• W4285185629 cites W2203529929 @default.
• W4285185629 cites W2211754517 @default.
• W4285185629 cites W2230590769 @default.
• W4285185629 cites W2335534790 @default.
• W4285185629 cites W2342486595 @default.
• W4285185629 cites W2495910804 @default.
• W4285185629 cites W2568498215 @default.
• W4285185629 cites W2572710398 @default.
• W4285185629 cites W2771853756 @default.
• W4285185629 cites W2786860261 @default.
• W4285185629 cites W2790770291 @default.
• W4285185629 cites W2793900597 @default.
• W4285185629 cites W2803057438 @default.
• W4285185629 cites W2807425198 @default.
• W4285185629 cites W2883519846 @default.
• W4285185629 cites W2888174646 @default.
• W4285185629 cites W2888973533 @default.
• W4285185629 cites W2897300390 @default.
• W4285185629 cites W2898819475 @default.
• W4285185629 cites W2904167846 @default.
• W4285185629 cites W2911603567 @default.
• W4285185629 cites W2948240989 @default.
• W4285185629 cites W2970959902 @default.
• W4285185629 cites W2973006025 @default.
• W4285185629 cites W2983855478 @default.
• W4285185629 cites W3004850275 @default.
• W4285185629 cites W3008198525 @default.
• W4285185629 cites W3041361526 @default.
• W4285185629 cites W3042183311 @default.
• W4285185629 cites W3067269879 @default.
• W4285185629 cites W3087501770 @default.
• W4285185629 cites W3092058471 @default.
• W4285185629 cites W3092538588 @default.
• W4285185629 cites W3113175786 @default.
• W4285185629 cites W3122857513 @default.
• W4285185629 cites W3128620467 @default.
• W4285185629 cites W3130252948 @default.
• W4285185629 cites W3135857099 @default.
• W4285185629 cites W3182356919 @default.
• W4285185629 cites W3184560250 @default.
• W4285185629 cites W3198871404 @default.
• W4285185629 cites W3215520922 @default.
• W4285185629 cites W3355293 @default.
• W4285185629 doi "https://doi.org/10.7150/thno.70929" @default.
• W4285185629 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/35673563" @default.
• W4285185629 hasPublicationYear "2022" @default.
• W4285185629 type Work @default.
• W4285185629 citedByCount "5" @default.
• W4285185629 countsByYear W42851856292022 @default.
• W4285185629 countsByYear W42851856292023 @default.
• W4285185629 crossrefType "journal-article" @default.
• W4285185629 hasAuthorship W4285185629A5001959448 @default.
• W4285185629 hasAuthorship W4285185629A5027048963 @default.
• W4285185629 hasAuthorship W4285185629A5032764121 @default.
• W4285185629 hasAuthorship W4285185629A5061469820 @default.
• W4285185629 hasAuthorship W4285185629A5088240691 @default.
• W4285185629 hasBestOaLocation W42851856291 @default.
• W4285185629 hasConcept C141071460 @default.
• W4285185629 hasConcept C142724271 @default.

• next