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- W4285187206 abstract "Diabetes is an ailment of multifactorial origin where metabolic, genetic, and environmental factors have a dominant role to play. The ever-increasing prevalence and complications associated with diabetes mellitus have expanded the research domain and have encouraged the out of the box thinking. In this direction the nutritional physiology and gastrointestinal tract associated control of biological mechanisms has gained much attention. The human gastrointestinal tract contains more than one thousand microorganisms that majorly include bacteria belonging to the bacteroidetes phyla. The intestinal microbial arrangement has found close association with several pathologies including peptic ulcer, inflammatory bowel diseases, asthma, cardiovascular complications, and endocrinal abnormalities including diabetes and dyslipidemia. The gut microbiota constitutes a dynamic environmental aspect that modulates the multifaceted network between genetic and environmental interfaces and influences the pathological progression of diabetes mellitus. The altered state of intestinal microbiota is characterized by increased intestinal permeability, decreased mucosal defense and reduction in tight junction proteins that favors translocation of bacterial lipopolysaccharides and inflammatory mediators into systemic circulation leading to altered immune and inflammatory responses detrimental for diabetes. The composition, properties, and integrity of microbiota may be influenced by probiotics. Probiotics are animate microbes that when used in appropriate quantities are well documented for their health promoting profits. Probiotics are investigated for a broad range of malfunctions including obesity, allergy, cardiovascular diseases, hepatitis, and cancer. Although use of probiotics offers a viable and dynamic approach to target molecule pathogenesis of diabetes mellitus (both type 1 and type 2) yet the major concerns include origin, safety, diagnostic identification, absence of genes that may be responsible for antibiotic resistance. The present work gives an insight into the molecular mechanism of probiotics in diabetes and includes reduction of oxidative stress, immunomodulation, improvement in absorption of antioxidants, anti-inflammatory action, and intervention in insulin resistance." @default.
- W4285187206 created "2022-07-14" @default.
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- W4285187206 date "2022-01-01" @default.
- W4285187206 modified "2023-10-17" @default.
- W4285187206 title "Mechanisms of Beneficial Effects of Probiotics in Diabetes Mellitus" @default.
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