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- W4285194601 abstract "Following a spinal cord injury (SCI), secondary injury leads to an environment that restricts axonal regeneration and ultimately functional recovery. A number of approaches have been developed to overcome this. However, delivery of compounds to the cord can be problematic due to poor stability, poor tissue penetration, and the potential for off target effects. Viral vector gene therapy is an approach to achieve long-term local delivery of therapeutic agents to the spinal cord. A number of different viral vectors are available and have been used to deliver therapeutic agents for SCI. Viral vectors also allow for different methods of delivery, either directly to the spinal cord for targeting of specific regions or via non-invasive remote delivery to muscle, nerves or via the blood stream. Viral vectors also allow for the spatiotemporal regulation of gene expression through the use of cell-specific promoters and inducible gene expression systems. This makes them a powerful tool for specific targeting of treatments. This chapter provides an overview of the types of viral vectors and delivery methods available. It gives examples of a number of different therapeutic approaches including delivery of neurotrophic factors and modulation of the glial scar and examples of how spatial and temporal regulation of gene expression has been used to effectively deliver treatments to the spinal cord." @default.
- W4285194601 created "2022-07-14" @default.
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- W4285194601 date "2022-01-01" @default.
- W4285194601 modified "2023-09-26" @default.
- W4285194601 title "Viral vector gene therapy approaches for regeneration and repair in spinal cord injury" @default.
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- W4285194601 doi "https://doi.org/10.1016/b978-0-12-822498-4.00032-4" @default.
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