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- W4285194792 abstract "Mounting evidence from clinical and nonclinical animal studies has implicated the recreational drug phencyclidine (PCP) as a central nervous system (CNS) toxicant. The morphological and behavioral abnormalities produced by PCP suggest alterations in the activity of multiple nervous system pathways, particularly glutamate neurotransmission. This chapter is an effort to delineate the relationship between behavioral deficits (e.g., locomotor sensitization) and neurotoxicity; to elucidate receptor mechanisms involved in neuronal damage and behavioral deficits; to describe the role of N-methyl-d-aspartate (NMDA) receptor upregulation in both phenomena (neurotoxicity and behavioral deficits); and to evaluate whether several candidate agents shown to be protective in other models of neurotoxicity can prevent or ameliorate any of the toxic effects associated with PCP-induced/related neurotoxicity. This chapter primarily focuses on the behavioral and neurobiological analyses of PCP-induced sensitization, neurotoxicity, and alterations in NMDA receptor expression during the brain growth spurt – a critical period of development. This chapter introduces a research platform with an overview of PCP, its potential for use as a tool to understand/dissect the neurobiological effects/mechanisms of repeated administration in PCP addiction and highlight its roles in developmental abnormalities of schizophrenia." @default.
- W4285194792 created "2022-07-14" @default.
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- W4285194792 date "2022-01-01" @default.
- W4285194792 modified "2023-10-18" @default.
- W4285194792 title "Phencyclidine (PCP)-induced neurotoxicity and behavioral deficits" @default.
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- W4285194792 doi "https://doi.org/10.1016/bs.ant.2022.04.005" @default.
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