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- W4285201739 abstract "This chapter reviews the best practices to establish an ovarian tissue cryopreservation program in your center. We share with you the worldwide regulatory experience in ovarian tissue cryopreservation and transplantation and point out to the areas of improvement. The laboratory efficacy of ovarian tissue cryopreservation (OTC) has been demonstrated through extensive preclinical research. The method has also proved to be clinically useful and it has also been exhaustively evaluated in clinical studies worldwide, becoming an innovative clinical option for fertility preservation. The success rates for regaining fertility after ovarian tissue transplantation has been reported in several cohorts and a metaanalysis, however, it is evident that there is still room for improvement to increase the efficacy of transplantation procedures and the final functionality of the grafted tissues. There is thus a need for continuous research on this topic. Programs for fertility preservation have been established within centers that perform other assisted reproductive technologies, which are already under regulatory conditions for the handling of human gamete cells and reproductive tissues. The centers offering OTC and ovarian tissue transplantation must have a rigorous quality control system. Legislations and regulations can vary among countries but the quality of these services must be under regulatory surveillance worldwide." @default.
- W4285201739 created "2022-07-14" @default.
- W4285201739 creator A5048744749 @default.
- W4285201739 date "2022-01-01" @default.
- W4285201739 modified "2023-10-16" @default.
- W4285201739 title "Regulatory Aspects of Ovarian Tissue Cryopreservation and Transplantation: How to Set Up a Program in Your Center" @default.
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- W4285201739 doi "https://doi.org/10.1016/b978-0-12-823344-3.00006-6" @default.
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