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- W4285220100 abstract "Traumatic brain injury (TBI) triggers the deformation of brain tissue followed by a detrimental cascade of biochemical reactions that impact many aspects of brain function. These reactions overcome the endogenous brain mechanisms designed to provide neuronal resiliency to injuries. Particularly, patients may express post-traumatic hypopituitarism associated with hypogonadism, which can be mirrored by decreased testosterone levels and impaired androgen receptors signaling in the brain. Testosterone exerts physiological neuromodulatory and neurotrophic roles associated with the increased synaptic connectivity and protein synthesis. Also, testosterone is capable of boosting mitochondrial bioenergetics and switching off apoptotic mechanisms. The loss of these functions after TBI has been coincident with deficient testosterone levels, which provides the basis to implicate this hormone in neuronal susceptibility to death. These endogenous properties in the brain highlight the potential of testosterone for drug-repurposing therapy against TBI." @default.
- W4285220100 created "2022-07-14" @default.
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- W4285220100 date "2022-01-01" @default.
- W4285220100 modified "2023-10-16" @default.
- W4285220100 title "Testosterone: Features and role in treating traumatic brain injury" @default.
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- W4285220100 doi "https://doi.org/10.1016/b978-0-12-823036-7.00006-2" @default.
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