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- W4285221562 abstract "Traumatic brain injury (TBI) is a leading cause of morbidity and mortality worldwide with a significant socioeconomic burden that attracts global concern. Besides the multi-factorial pathophysiology of TBI, including blood–brain barrier (BBB) disruption, oxidative stress, and apoptosis, recent studies have highlighted the key role of the immune system in TBI, especially the autoimmune reactions post-injury, and the driven leakage of immune cells along with their breakdown products (i.e., autoantibodies) into the brain parenchyma and biofluids. Such autoantibodies can be of a prospective role as potential biomarkers indicative of the corresponding pathophysiological mechanisms following the injury. In the following chapter, we present an overview of the immune cascade following TBI, a compendium of the most reliable TBI biomarkers, their diagnostic and prognostic prospect to assess the severity of the injury, and envisage the clinical outcomes, respectively. Moreover, we elucidate the pathophysiological mechanisms of autoimmunity triggered by B-cell activation and how this could be a potential therapeutic target in TBI." @default.
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- W4285221562 date "2022-01-01" @default.
- W4285221562 modified "2023-09-30" @default.
- W4285221562 title "Brain injury biomarkers: Proteins and autoantibodies interplay" @default.
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- W4285221562 doi "https://doi.org/10.1016/b978-0-12-823347-4.00036-1" @default.
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