Matches in SemOpenAlex for { <https://semopenalex.org/work/W4285223822> ?p ?o ?g. }
- W4285223822 endingPage "734" @default.
- W4285223822 startingPage "711" @default.
- W4285223822 abstract "Bacterial histidine kinases (HKs) are potential targets for novel antimicrobials. Bacterial HKs are part of the bacterial two-component system (TCS), the key pathway for signal transduction in bacteria that regulate several processes like secretion systems, virulence, and antibiotic resistance. The microbial population in a broad range of environmental conditions sense and respond to various external stimuli for their survival. Histidine kinases are unique to each external stimulus, and these are highly conserved, which implies broad-spectrum antibacterial activity to the inhibitors targeting this site. This chapter would outline our current understanding of the structure and function of histidine kinase and the development of antimicrobials targeting histidine kinase stimulated signal transduction and its succeeding regulation of gene expression system. Furthermore, we will discuss some of the inhibitors that have been reported to target HKs in pathogenic bacteria." @default.
- W4285223822 created "2022-07-14" @default.
- W4285223822 creator A5013352660 @default.
- W4285223822 creator A5052838748 @default.
- W4285223822 creator A5077646955 @default.
- W4285223822 date "2022-01-01" @default.
- W4285223822 modified "2023-10-18" @default.
- W4285223822 title "Bacterial histidine kinases as potential antibacterial drug targets" @default.
- W4285223822 cites W1493769942 @default.
- W4285223822 cites W1601146610 @default.
- W4285223822 cites W1754969498 @default.
- W4285223822 cites W1846561288 @default.
- W4285223822 cites W1958031489 @default.
- W4285223822 cites W1965573018 @default.
- W4285223822 cites W1968026783 @default.
- W4285223822 cites W1969808346 @default.
- W4285223822 cites W1971496855 @default.
- W4285223822 cites W1973851889 @default.
- W4285223822 cites W1975364318 @default.
- W4285223822 cites W1980595924 @default.
- W4285223822 cites W1983157241 @default.
- W4285223822 cites W1990688956 @default.
- W4285223822 cites W1991371091 @default.
- W4285223822 cites W1995053766 @default.
- W4285223822 cites W1996560233 @default.
- W4285223822 cites W1999189021 @default.
- W4285223822 cites W2002159459 @default.
- W4285223822 cites W2003443461 @default.
- W4285223822 cites W2007045108 @default.
- W4285223822 cites W2008200635 @default.
- W4285223822 cites W2008630890 @default.
- W4285223822 cites W2011602494 @default.
- W4285223822 cites W2015569838 @default.
- W4285223822 cites W2020962641 @default.
- W4285223822 cites W2023184347 @default.
- W4285223822 cites W2025255235 @default.
- W4285223822 cites W2026677195 @default.
- W4285223822 cites W2028005568 @default.
- W4285223822 cites W2028410153 @default.
- W4285223822 cites W2028874353 @default.
- W4285223822 cites W2032898080 @default.
- W4285223822 cites W2033058355 @default.
- W4285223822 cites W2033591223 @default.
- W4285223822 cites W2034716199 @default.
- W4285223822 cites W2041233780 @default.
- W4285223822 cites W2041844212 @default.
- W4285223822 cites W2044357547 @default.
- W4285223822 cites W2048661284 @default.
- W4285223822 cites W2051049929 @default.
- W4285223822 cites W2051830305 @default.
- W4285223822 cites W2056969605 @default.
- W4285223822 cites W2062972150 @default.
- W4285223822 cites W2063635078 @default.
- W4285223822 cites W2065177682 @default.
- W4285223822 cites W2068254342 @default.
- W4285223822 cites W2073339325 @default.
- W4285223822 cites W2077396167 @default.
- W4285223822 cites W2078544581 @default.
- W4285223822 cites W2085729235 @default.
- W4285223822 cites W2092131410 @default.
- W4285223822 cites W2093561372 @default.
- W4285223822 cites W2094566428 @default.
- W4285223822 cites W2094741750 @default.
- W4285223822 cites W2098884036 @default.
- W4285223822 cites W2101580369 @default.
- W4285223822 cites W2102768869 @default.
- W4285223822 cites W2110055201 @default.
- W4285223822 cites W2113410040 @default.
- W4285223822 cites W2115006373 @default.
- W4285223822 cites W2116043155 @default.
- W4285223822 cites W2118585647 @default.
- W4285223822 cites W2124866674 @default.
- W4285223822 cites W2125052421 @default.
- W4285223822 cites W2128169009 @default.
- W4285223822 cites W2131731929 @default.
- W4285223822 cites W2131959708 @default.
- W4285223822 cites W2134069557 @default.
- W4285223822 cites W2135736895 @default.
- W4285223822 cites W2136326574 @default.
- W4285223822 cites W2138243191 @default.
- W4285223822 cites W2138818402 @default.
- W4285223822 cites W2141567446 @default.
- W4285223822 cites W2145161827 @default.
- W4285223822 cites W2145443843 @default.
- W4285223822 cites W2152863678 @default.
- W4285223822 cites W2153571553 @default.
- W4285223822 cites W2155762470 @default.
- W4285223822 cites W2161178127 @default.
- W4285223822 cites W2164101095 @default.
- W4285223822 cites W2167499618 @default.
- W4285223822 cites W2169940011 @default.
- W4285223822 cites W265173346 @default.
- W4285223822 cites W2764155647 @default.
- W4285223822 cites W2953786747 @default.
- W4285223822 cites W3007361194 @default.
- W4285223822 cites W4254655724 @default.
- W4285223822 doi "https://doi.org/10.1016/b978-0-323-91287-7.00025-9" @default.
- W4285223822 hasPublicationYear "2022" @default.