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- W4285238013 abstract "Biventricular failure affects an extremely ill cohort of patients who have end-stage heart disease that involves both ventricles. Patients with biventricular assist devices experience a high incidence of adverse events and low 1-year survival. With regard to pump type, this condition continues to limit the long-term success of mechanical circulatory support therapies, and so demands timely intervention to sustain deteriorating hemodynamics and to facilitate symptomatic improvements. Currently, there is no durable right ventricular assist device (RVAD) available to treat right heart failure. Existing ventricular assist devices are not designed for right ventricular support, but are specific to left ventricular assist device (LVAD) operational range. An innovative, universal ventricular assist device (UVAD) is being developed for widespread use, or for use as an RVAD or LVAD, making it suitable for right or left heart assist, or biventricular support, while utilizing an automatic and dynamic pump performance regulation feature also found in our continuous-flow total artificial heart. Our UVAD development is described, and we report device performance evaluations for in vitro and in vivo conditions, the results of computational fluid dynamics, an overview of the research and engineering processes that have been instrumental in the fabrication of advanced prototype devices and iterations, and biocompatibility testing of the UVAD design over a range of simulated hemodynamic conditions." @default.
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- W4285238013 date "2022-01-01" @default.
- W4285238013 modified "2023-10-04" @default.
- W4285238013 title "Research and Development for Creating a Universal Ventricular Assist Device" @default.
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- W4285238013 doi "https://doi.org/10.1016/b978-0-12-816861-5.00039-3" @default.
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