Matches in SemOpenAlex for { <https://semopenalex.org/work/W4285239666> ?p ?o ?g. }
- W4285239666 endingPage "166" @default.
- W4285239666 startingPage "145" @default.
- W4285239666 abstract "G protein-coupled receptors (GPCRs) play pivotal roles in regulation of cardiovascular homeostasis across all vertebrate species, including humans. In terms of normal cellular function, termination of GPCR signaling via the heterotrimeric G proteins is equally (if not more) important to its stimulation. The Regulator of G protein Signaling (RGS) protein superfamily are indispensable for GPCR signaling cessation at the cell membrane, and thus, for cellular control of GPCR signaling and function. Perturbations in both activation and termination of G protein signaling underlie many examples of cardiovascular dysfunction and heart disease pathogenesis. Despite the plethora of over 30 members comprising the mammalian RGS protein superfamily, each member interacts with a specific set of second messenger pathways and GPCR types/subtypes in a tissue/cell type-specific manner. An increasing number of studies over the past two decades have provided compelling evidence for the involvement of various RGS proteins in physiological regulation of cardiovascular GPCRs and, consequently, also in the pathophysiology of several cardiovascular ailments. This chapter summarizes the current understanding of the functional roles of RGS proteins as they pertain to cardiovascular, i.e., heart, blood vessel, and platelet GPCR function, with a particular focus on their implications for chronic heart failure pathophysiology and therapy." @default.
- W4285239666 created "2022-07-14" @default.
- W4285239666 creator A5019188547 @default.
- W4285239666 creator A5032748291 @default.
- W4285239666 creator A5053143997 @default.
- W4285239666 date "2022-01-01" @default.
- W4285239666 modified "2023-10-01" @default.
- W4285239666 title "Cardiovascular GPCR regulation by regulator of G protein signaling proteins" @default.
- W4285239666 cites W1470476341 @default.
- W4285239666 cites W1483452749 @default.
- W4285239666 cites W1504974528 @default.
- W4285239666 cites W1509389952 @default.
- W4285239666 cites W1510328954 @default.
- W4285239666 cites W1538257698 @default.
- W4285239666 cites W1592140990 @default.
- W4285239666 cites W1914256230 @default.
- W4285239666 cites W1939413675 @default.
- W4285239666 cites W1953109900 @default.
- W4285239666 cites W1971707438 @default.
- W4285239666 cites W1977493444 @default.
- W4285239666 cites W1978144617 @default.
- W4285239666 cites W1987510108 @default.
- W4285239666 cites W1988215184 @default.
- W4285239666 cites W1989347792 @default.
- W4285239666 cites W1996738230 @default.
- W4285239666 cites W1998494333 @default.
- W4285239666 cites W1999583992 @default.
- W4285239666 cites W2006547317 @default.
- W4285239666 cites W2009415839 @default.
- W4285239666 cites W2010688793 @default.
- W4285239666 cites W2011209372 @default.
- W4285239666 cites W2013245863 @default.
- W4285239666 cites W2015910746 @default.
- W4285239666 cites W2018502318 @default.
- W4285239666 cites W2022578547 @default.
- W4285239666 cites W2025929854 @default.
- W4285239666 cites W2026394050 @default.
- W4285239666 cites W2027896877 @default.
- W4285239666 cites W2033812812 @default.
- W4285239666 cites W2036337541 @default.
- W4285239666 cites W2040296648 @default.
- W4285239666 cites W2058562094 @default.
- W4285239666 cites W2058801184 @default.
- W4285239666 cites W2061472003 @default.
- W4285239666 cites W2064664612 @default.
- W4285239666 cites W2070933984 @default.
- W4285239666 cites W2071242185 @default.
- W4285239666 cites W2071806226 @default.
- W4285239666 cites W2072610074 @default.
- W4285239666 cites W2084440251 @default.
- W4285239666 cites W2087107619 @default.
- W4285239666 cites W2087502638 @default.
- W4285239666 cites W2089919670 @default.
- W4285239666 cites W2105178435 @default.
- W4285239666 cites W2105567563 @default.
- W4285239666 cites W2108280966 @default.
- W4285239666 cites W2110322730 @default.
- W4285239666 cites W2110458673 @default.
- W4285239666 cites W2115617980 @default.
- W4285239666 cites W2128665362 @default.
- W4285239666 cites W2130223518 @default.
- W4285239666 cites W2131374289 @default.
- W4285239666 cites W2133321625 @default.
- W4285239666 cites W2135239798 @default.
- W4285239666 cites W2136746722 @default.
- W4285239666 cites W2136972830 @default.
- W4285239666 cites W2138750274 @default.
- W4285239666 cites W2139367613 @default.
- W4285239666 cites W2142580113 @default.
- W4285239666 cites W2146386420 @default.
- W4285239666 cites W2149694490 @default.
- W4285239666 cites W2149736002 @default.
- W4285239666 cites W2153440566 @default.
- W4285239666 cites W2154335322 @default.
- W4285239666 cites W2156802607 @default.
- W4285239666 cites W2157201312 @default.
- W4285239666 cites W2159943707 @default.
- W4285239666 cites W2162250890 @default.
- W4285239666 cites W2165148544 @default.
- W4285239666 cites W2165484599 @default.
- W4285239666 cites W2171451259 @default.
- W4285239666 cites W2179510469 @default.
- W4285239666 cites W2180339206 @default.
- W4285239666 cites W2187929376 @default.
- W4285239666 cites W2333886382 @default.
- W4285239666 cites W2346506470 @default.
- W4285239666 cites W2394714336 @default.
- W4285239666 cites W2412663004 @default.
- W4285239666 cites W2554470111 @default.
- W4285239666 cites W2765153686 @default.
- W4285239666 cites W2771087837 @default.
- W4285239666 cites W2782382515 @default.
- W4285239666 cites W2793514054 @default.
- W4285239666 cites W2794568828 @default.
- W4285239666 cites W2800232824 @default.
- W4285239666 cites W2806782218 @default.
- W4285239666 cites W2809303314 @default.
- W4285239666 cites W2809307170 @default.