Matches in SemOpenAlex for { <https://semopenalex.org/work/W4285245551> ?p ?o ?g. }
- W4285245551 endingPage "3757" @default.
- W4285245551 startingPage "3747" @default.
- W4285245551 abstract "Rationale: In combination chemotherapy, the molar ratio of drugs is a critical parameter that determines the synergistic effects. However, most co-delivery vectors are incapable of maintaining the optimal molar ratio of drugs throughout the delivery process. Herein, a calixarene-modified albumin (CaMA), which can co-deliver multiple drugs with precise control of the drug ratio, is presented. Methods: CaMA was prepared by chemically conjugating multiple sulfonate azocalix[4]arenes (SAC4A) onto the surface of bovine serum albumin (BSA). The precise drug loading and synchronous drug release were measured using fluorescence spectroscopy. Mouse tumor cell 4T1 and 4T1-bearing mice were used to evaluate the combined effects of mitomycin C (MMC) and doxorubicin (DOX) in vitro and in vivo. Results: With multiple hypoxia-responsive calixarenes conjugated onto a single albumin molecule, CaMA achieved precise drug loading and synchronous release of multiple drugs into the tumor microenvironment. This unique drug loading and release mechanism ensures that CaMA maintains the drug ratio from the initial drug loading to the release site, providing a solid foundation for multi-drug combination therapy with the goal of achieving predictable therapeutic outcomes in vivo. The delivery of the model drug combination MMC and DOX at a prescreened ratio via CaMA achieved significantly enhanced tumor suppression and reduced systemic toxicity. Conclusions: This stoichiometric delivery feature makes CaMA a powerful tool for the development of combination chemotherapy and personalized medications for cancer treatment." @default.
- W4285245551 created "2022-07-14" @default.
- W4285245551 creator A5010215560 @default.
- W4285245551 creator A5018863416 @default.
- W4285245551 creator A5022217280 @default.
- W4285245551 creator A5023363049 @default.
- W4285245551 creator A5042108742 @default.
- W4285245551 creator A5047225525 @default.
- W4285245551 creator A5053414236 @default.
- W4285245551 creator A5065252882 @default.
- W4285245551 creator A5072124571 @default.
- W4285245551 date "2022-01-01" @default.
- W4285245551 modified "2023-10-16" @default.
- W4285245551 title "Calixarene-modified albumin for stoichiometric delivery of multiple drugs in combination-chemotherapy" @default.
- W4285245551 cites W1965636780 @default.
- W4285245551 cites W1994881394 @default.
- W4285245551 cites W2000691433 @default.
- W4285245551 cites W2061136308 @default.
- W4285245551 cites W2063254240 @default.
- W4285245551 cites W2066484074 @default.
- W4285245551 cites W2096439168 @default.
- W4285245551 cites W2162994503 @default.
- W4285245551 cites W2165921162 @default.
- W4285245551 cites W2260188081 @default.
- W4285245551 cites W2411107198 @default.
- W4285245551 cites W2600277110 @default.
- W4285245551 cites W2638953127 @default.
- W4285245551 cites W2748417965 @default.
- W4285245551 cites W2762136999 @default.
- W4285245551 cites W2792801574 @default.
- W4285245551 cites W2900493058 @default.
- W4285245551 cites W2901259289 @default.
- W4285245551 cites W2904891478 @default.
- W4285245551 cites W2905770987 @default.
- W4285245551 cites W2911425042 @default.
- W4285245551 cites W2912464701 @default.
- W4285245551 cites W2922267926 @default.
- W4285245551 cites W2929514848 @default.
- W4285245551 cites W2936513263 @default.
- W4285245551 cites W2945704585 @default.
- W4285245551 cites W2994732061 @default.
- W4285245551 cites W3010811779 @default.
- W4285245551 cites W3028868129 @default.
- W4285245551 cites W3040880602 @default.
- W4285245551 cites W3080943003 @default.
- W4285245551 cites W3081100275 @default.
- W4285245551 cites W3096109417 @default.
- W4285245551 cites W3118339526 @default.
- W4285245551 cites W3129798610 @default.
- W4285245551 cites W3159585736 @default.
- W4285245551 cites W3164006366 @default.
- W4285245551 cites W3174769180 @default.
- W4285245551 cites W3177238129 @default.
- W4285245551 cites W3185164190 @default.
- W4285245551 cites W3190444638 @default.
- W4285245551 cites W3214649307 @default.
- W4285245551 cites W4206692131 @default.
- W4285245551 cites W4210961063 @default.
- W4285245551 cites W4231038223 @default.
- W4285245551 cites W4239842495 @default.
- W4285245551 doi "https://doi.org/10.7150/thno.72559" @default.
- W4285245551 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/35664058" @default.
- W4285245551 hasPublicationYear "2022" @default.
- W4285245551 type Work @default.
- W4285245551 citedByCount "7" @default.
- W4285245551 countsByYear W42852455512022 @default.
- W4285245551 countsByYear W42852455512023 @default.
- W4285245551 crossrefType "journal-article" @default.
- W4285245551 hasAuthorship W4285245551A5010215560 @default.
- W4285245551 hasAuthorship W4285245551A5018863416 @default.
- W4285245551 hasAuthorship W4285245551A5022217280 @default.
- W4285245551 hasAuthorship W4285245551A5023363049 @default.
- W4285245551 hasAuthorship W4285245551A5042108742 @default.
- W4285245551 hasAuthorship W4285245551A5047225525 @default.
- W4285245551 hasAuthorship W4285245551A5053414236 @default.
- W4285245551 hasAuthorship W4285245551A5065252882 @default.
- W4285245551 hasAuthorship W4285245551A5072124571 @default.
- W4285245551 hasBestOaLocation W42852455511 @default.
- W4285245551 hasConcept C141071460 @default.
- W4285245551 hasConcept C150903083 @default.
- W4285245551 hasConcept C178790620 @default.
- W4285245551 hasConcept C185592680 @default.
- W4285245551 hasConcept C207001950 @default.
- W4285245551 hasConcept C2776125364 @default.
- W4285245551 hasConcept C2776694085 @default.
- W4285245551 hasConcept C2779338040 @default.
- W4285245551 hasConcept C2779820397 @default.
- W4285245551 hasConcept C2780035454 @default.
- W4285245551 hasConcept C2781303535 @default.
- W4285245551 hasConcept C43617362 @default.
- W4285245551 hasConcept C55493867 @default.
- W4285245551 hasConcept C71924100 @default.
- W4285245551 hasConcept C86803240 @default.
- W4285245551 hasConcept C86807702 @default.
- W4285245551 hasConcept C98274493 @default.
- W4285245551 hasConceptScore W4285245551C141071460 @default.
- W4285245551 hasConceptScore W4285245551C150903083 @default.
- W4285245551 hasConceptScore W4285245551C178790620 @default.