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- W4285247722 abstract "Mechanoelectric feedback manifests itself in a change in myocardial conductivity and in the appearance of additional transmembrane currents associated with strain-activated ion channels. Modeling of the effect of changes in intracellular conductivity on electrical processes in the myocardium is considered. When the excitation wave propagates in the myocardium, the influence of the deformation is diluted by the extracellular conductivity, which is weakly dependent on the deformation. Deformation has a much greater influence on those effects where the intracellular and extracellular media play more independent roles. One of these effects is the formation of virtual electrodes as areas of depolarization and hyperpolarization that occur when an electric current is applied to the myocardium in a small area. Two variants of deformation are considered: tension along the fibers and shear parallel to the fibers. In the case of shear, the virtual electrodes may rotate towards the main deformation axes. Another task is to polarize a strip of cardiac tissue with isolated boundaries and fibers approaching them at an angle when an electric current flows along it. Here, an exact analytical solution can be obtained for both an undeformed and a uniformly deformed strip. A model of channel activation under complex deformation is constructed, based on the assumption that these channels respond to a local increase in the area of the membrane section. Two options for the location of activated channels are considered: uniform distribution on the outer surface of the cell and uniform distribution in t-tubules, that is special invaginations of the cell membrane located perpendicular to the lateral surface. The proportion of membrane regions in the state of stretching, where the channels can be activated, has been found." @default.
- W4285247722 created "2022-07-14" @default.
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- W4285247722 date "2022-01-01" @default.
- W4285247722 modified "2023-09-30" @default.
- W4285247722 title "Building the models of interaction of electrical and deformation processes in the cardiac tissue" @default.
- W4285247722 doi "https://doi.org/10.7242/2658-705x/2022.1.6" @default.
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