Matches in SemOpenAlex for { <https://semopenalex.org/work/W4285249625> ?p ?o ?g. }
- W4285249625 endingPage "175883592210968" @default.
- W4285249625 startingPage "175883592210968" @default.
- W4285249625 abstract "Recently, new evidence of the next-generation sequencing (NGS) liquid biopsy utility in clinical practice has been developed. This assay is emerging as a new promising tool to use as a noninvasive biomarker for cancer mutation profiling. Additional data supporting the clinical validity of cell free DNA (cfDNA) based testing is necessary to inform optimal use of these assays in the clinic.A total of 398 cancer patients were analyzed by FoundationOne Liquid Analysis (F1LA), a genomic profiling assay and by standard NGS diagnostic ThermoFisher platform. The association between diagnostic technique was evaluated using a Poisson regression model. FoundationOne Liquid (F1L) and FoundationOne Liquid CDx (F1LCDx) detect 70 and 324 cancer-related genes alterations, respectively, including genomic signatures tumor fraction, blood tumor mutational burden (only for the 324 genes version), and microsatellite instability high status. Both assays used a single DNA extraction method to obtain cfDNA. The real-life clinical impact and feasibility of F1L and F1LCDx were evaluated across different solid tumors in our department.Between 1 January 2019 and 28 February 2021, 398 samples of different tumor types from 398 patients were analyzed (overall success rate: 92%, in FoundationOne Liquid CDx Analysis success rate: 97%). Most frequent molecular alterations were TP53 (74), APC (40), DNMT3A (39), KRAS (23). The comprehensive clinical impact of F1LA compared with standard diagnostic was 64.7% versus 22.1% [risk ratio (RR) = 2.94; p < 0.001] and the potential clinical impact was 58.6% versus 11.0% (RR = 5.32; p < 0.001), respectively. Furthermore, some clinical cases were selected, in which F1LA detected actionable alterations offering an unexpected therapeutic choice.Although additional studies are needed to better select patients and setting, NGS F1LA is a useful, noninvasive, and repeatable assay to guide therapeutic choice in oncology. It provides a snapshot of cancer heterogeneity profile that could be incorporated in routinely clinical practice." @default.
- W4285249625 created "2022-07-14" @default.
- W4285249625 creator A5000656275 @default.
- W4285249625 creator A5002124283 @default.
- W4285249625 creator A5004016643 @default.
- W4285249625 creator A5009130863 @default.
- W4285249625 creator A5012201620 @default.
- W4285249625 creator A5013462294 @default.
- W4285249625 creator A5013734061 @default.
- W4285249625 creator A5018998789 @default.
- W4285249625 creator A5020655022 @default.
- W4285249625 creator A5028284107 @default.
- W4285249625 creator A5034064734 @default.
- W4285249625 creator A5037047992 @default.
- W4285249625 creator A5038305710 @default.
- W4285249625 creator A5043177546 @default.
- W4285249625 creator A5047539709 @default.
- W4285249625 creator A5060459960 @default.
- W4285249625 creator A5067376970 @default.
- W4285249625 creator A5073891277 @default.
- W4285249625 creator A5074105754 @default.
- W4285249625 creator A5076690603 @default.
- W4285249625 date "2022-01-01" @default.
- W4285249625 modified "2023-10-01" @default.
- W4285249625 title "Comprehensive genome profiling by next generation sequencing of circulating tumor DNA in solid tumors: a single academic institution experience" @default.
- W4285249625 cites W1904761682 @default.
- W4285249625 cites W2070059866 @default.
- W4285249625 cites W2135924719 @default.
- W4285249625 cites W2408112818 @default.
- W4285249625 cites W2424762432 @default.
- W4285249625 cites W2494541315 @default.
- W4285249625 cites W2598551510 @default.
- W4285249625 cites W2620581814 @default.
- W4285249625 cites W2761067356 @default.
- W4285249625 cites W2792694005 @default.
- W4285249625 cites W2793825788 @default.
- W4285249625 cites W2800526885 @default.
- W4285249625 cites W2809244864 @default.
- W4285249625 cites W2888992486 @default.
- W4285249625 cites W2918277820 @default.
- W4285249625 cites W2943567636 @default.
- W4285249625 cites W2948359678 @default.
- W4285249625 cites W2965555612 @default.
- W4285249625 cites W2979386314 @default.
- W4285249625 cites W2980702146 @default.
- W4285249625 cites W2981966630 @default.
- W4285249625 cites W2983333840 @default.
- W4285249625 cites W3015161417 @default.
- W4285249625 cites W3015202523 @default.
- W4285249625 cites W3031159445 @default.
- W4285249625 cites W3039360174 @default.
- W4285249625 cites W3041255266 @default.
- W4285249625 cites W3088519161 @default.
- W4285249625 cites W3088621202 @default.
- W4285249625 cites W3089393284 @default.
- W4285249625 cites W3096158121 @default.
- W4285249625 cites W3113200784 @default.
- W4285249625 cites W3114503054 @default.
- W4285249625 cites W3118092840 @default.
- W4285249625 cites W3135524344 @default.
- W4285249625 cites W3135821078 @default.
- W4285249625 cites W3152831908 @default.
- W4285249625 cites W3153990830 @default.
- W4285249625 cites W3170845821 @default.
- W4285249625 cites W3184825054 @default.
- W4285249625 cites W3199663433 @default.
- W4285249625 cites W4205724345 @default.
- W4285249625 doi "https://doi.org/10.1177/17588359221096878" @default.
- W4285249625 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/35547096" @default.
- W4285249625 hasPublicationYear "2022" @default.
- W4285249625 type Work @default.
- W4285249625 citedByCount "7" @default.
- W4285249625 countsByYear W42852496252022 @default.
- W4285249625 countsByYear W42852496252023 @default.
- W4285249625 crossrefType "journal-article" @default.
- W4285249625 hasAuthorship W4285249625A5000656275 @default.
- W4285249625 hasAuthorship W4285249625A5002124283 @default.
- W4285249625 hasAuthorship W4285249625A5004016643 @default.
- W4285249625 hasAuthorship W4285249625A5009130863 @default.
- W4285249625 hasAuthorship W4285249625A5012201620 @default.
- W4285249625 hasAuthorship W4285249625A5013462294 @default.
- W4285249625 hasAuthorship W4285249625A5013734061 @default.
- W4285249625 hasAuthorship W4285249625A5018998789 @default.
- W4285249625 hasAuthorship W4285249625A5020655022 @default.
- W4285249625 hasAuthorship W4285249625A5028284107 @default.
- W4285249625 hasAuthorship W4285249625A5034064734 @default.
- W4285249625 hasAuthorship W4285249625A5037047992 @default.
- W4285249625 hasAuthorship W4285249625A5038305710 @default.
- W4285249625 hasAuthorship W4285249625A5043177546 @default.
- W4285249625 hasAuthorship W4285249625A5047539709 @default.
- W4285249625 hasAuthorship W4285249625A5060459960 @default.
- W4285249625 hasAuthorship W4285249625A5067376970 @default.
- W4285249625 hasAuthorship W4285249625A5073891277 @default.
- W4285249625 hasAuthorship W4285249625A5074105754 @default.
- W4285249625 hasAuthorship W4285249625A5076690603 @default.
- W4285249625 hasBestOaLocation W42852496251 @default.
- W4285249625 hasConcept C104317684 @default.
- W4285249625 hasConcept C121608353 @default.