Matches in SemOpenAlex for { <https://semopenalex.org/work/W4285252634> ?p ?o ?g. }
- W4285252634 endingPage "990" @default.
- W4285252634 startingPage "978" @default.
- W4285252634 abstract "Diabetic nephropathy (DN) is one of the chronic microvascular diseases of diabetes. Studies revealed that inflammation is involved in the development of DN. However, its mechanisms are not fully clear. Here, we screened DN-related mRNAs by RNA sequencing in the renal tissues of db/db DN mice and normal control mice. The Swiss-Model, ZDOCK 3.0.2 and PyMOL 2.3.2 were applied for bioinformatics analysis. In total, we obtained 6,820 mRNAs that were dysexpressed in DN. Among them, Receptor for Activated C Kinase 1 (Rack1) was focused on for its high fold changes and high values of fragments per kilobase million (FPKM) in both two groups (FPKM >100). Moreover, Rack1 was highly expressed in DN in vivo and in vitro. Results displayed that the expressions of pro-inflammatory cytokines Mcp-1 and Tnf-α were increased when Rack1 was overexpressed in cells cultured with low glucose while the expressions of Mcp-1 and Tnf-α were decreased when Rack1 was silenced in cells cultured with high glucose. Furthermore, results showed that the established DN inflammatory factor nuclear factor NF-kappa-B (NF-κB) was regulated by Rack1 via the direct interaction between Rack1 and NF-κB subunits P50 and P65. In summary, this identified Rack1 could play an important role in the inflammation of DN via NF-κB, which can provide new insight for DN research." @default.
- W4285252634 created "2022-07-14" @default.
- W4285252634 creator A5018700814 @default.
- W4285252634 creator A5026082024 @default.
- W4285252634 creator A5037702659 @default.
- W4285252634 creator A5049728628 @default.
- W4285252634 creator A5065824242 @default.
- W4285252634 creator A5085728589 @default.
- W4285252634 creator A5088023001 @default.
- W4285252634 creator A5088888083 @default.
- W4285252634 creator A5088891835 @default.
- W4285252634 date "2022-01-01" @default.
- W4285252634 modified "2023-09-30" @default.
- W4285252634 title "Rack1 regulates pro-inflammatory cytokines by NF-κB in diabetic nephropathy" @default.
- W4285252634 cites W1984667010 @default.
- W4285252634 cites W1992178421 @default.
- W4285252634 cites W2004675829 @default.
- W4285252634 cites W2020133142 @default.
- W4285252634 cites W2022802363 @default.
- W4285252634 cites W2061172276 @default.
- W4285252634 cites W2069686033 @default.
- W4285252634 cites W2073882423 @default.
- W4285252634 cites W2085673832 @default.
- W4285252634 cites W2094273616 @default.
- W4285252634 cites W2099816894 @default.
- W4285252634 cites W2101844105 @default.
- W4285252634 cites W2118165245 @default.
- W4285252634 cites W2119731784 @default.
- W4285252634 cites W2122981222 @default.
- W4285252634 cites W2125326130 @default.
- W4285252634 cites W2127719372 @default.
- W4285252634 cites W2138640452 @default.
- W4285252634 cites W2144774384 @default.
- W4285252634 cites W2160332942 @default.
- W4285252634 cites W2161132697 @default.
- W4285252634 cites W2164249826 @default.
- W4285252634 cites W2166542841 @default.
- W4285252634 cites W2251007344 @default.
- W4285252634 cites W2252346101 @default.
- W4285252634 cites W2410592318 @default.
- W4285252634 cites W2419906038 @default.
- W4285252634 cites W2475508157 @default.
- W4285252634 cites W2492843773 @default.
- W4285252634 cites W2512180685 @default.
- W4285252634 cites W2518283902 @default.
- W4285252634 cites W2562194704 @default.
- W4285252634 cites W2585789979 @default.
- W4285252634 cites W2742882848 @default.
- W4285252634 cites W2886973333 @default.
- W4285252634 cites W2897311661 @default.
- W4285252634 cites W2900586169 @default.
- W4285252634 cites W2906886777 @default.
- W4285252634 cites W2971659966 @default.
- W4285252634 cites W2989137219 @default.
- W4285252634 cites W2991978450 @default.
- W4285252634 cites W2999140222 @default.
- W4285252634 cites W3000357315 @default.
- W4285252634 cites W3008901037 @default.
- W4285252634 cites W3027857678 @default.
- W4285252634 cites W4210422119 @default.
- W4285252634 cites W4231142430 @default.
- W4285252634 cites W4256429613 @default.
- W4285252634 doi "https://doi.org/10.1515/med-2022-0487" @default.
- W4285252634 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/35663595" @default.
- W4285252634 hasPublicationYear "2022" @default.
- W4285252634 type Work @default.
- W4285252634 citedByCount "3" @default.
- W4285252634 countsByYear W42852526342023 @default.
- W4285252634 crossrefType "journal-article" @default.
- W4285252634 hasAuthorship W4285252634A5018700814 @default.
- W4285252634 hasAuthorship W4285252634A5026082024 @default.
- W4285252634 hasAuthorship W4285252634A5037702659 @default.
- W4285252634 hasAuthorship W4285252634A5049728628 @default.
- W4285252634 hasAuthorship W4285252634A5065824242 @default.
- W4285252634 hasAuthorship W4285252634A5085728589 @default.
- W4285252634 hasAuthorship W4285252634A5088023001 @default.
- W4285252634 hasAuthorship W4285252634A5088888083 @default.
- W4285252634 hasAuthorship W4285252634A5088891835 @default.
- W4285252634 hasBestOaLocation W42852526341 @default.
- W4285252634 hasConcept C104317684 @default.
- W4285252634 hasConcept C105580179 @default.
- W4285252634 hasConcept C123298856 @default.
- W4285252634 hasConcept C126322002 @default.
- W4285252634 hasConcept C134018914 @default.
- W4285252634 hasConcept C153911025 @default.
- W4285252634 hasConcept C164027704 @default.
- W4285252634 hasConcept C170493617 @default.
- W4285252634 hasConcept C17991360 @default.
- W4285252634 hasConcept C207001950 @default.
- W4285252634 hasConcept C2776914184 @default.
- W4285252634 hasConcept C2777730290 @default.
- W4285252634 hasConcept C2779922275 @default.
- W4285252634 hasConcept C502942594 @default.
- W4285252634 hasConcept C54355233 @default.
- W4285252634 hasConcept C55493867 @default.
- W4285252634 hasConcept C555293320 @default.
- W4285252634 hasConcept C71924100 @default.
- W4285252634 hasConcept C86339819 @default.