FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4285258313> ?p ?o ?g. }

• W4285258313 endingPage "74" @default.
• W4285258313 startingPage "62" @default.
• W4285258313 abstract "Single-photon emission-computed tomography (SPECT) provides a mechanism to estimate regional isotope uptake in lesions and at-risk organs after administration of <inline-formula xmlns:mml=http://www.w3.org/1998/Math/MathML xmlns:xlink=http://www.w3.org/1999/xlink> <tex-math notation=LaTeX>$alpha $ </tex-math></inline-formula> -particle-emitting radiopharmaceutical therapies ( <inline-formula xmlns:mml=http://www.w3.org/1998/Math/MathML xmlns:xlink=http://www.w3.org/1999/xlink> <tex-math notation=LaTeX>$alpha $ </tex-math></inline-formula> -RPTs). However, this estimation task is challenging due to the complex emission spectra, the very low number of detected counts ( <inline-formula xmlns:mml=http://www.w3.org/1998/Math/MathML xmlns:xlink=http://www.w3.org/1999/xlink> <tex-math notation=LaTeX>$sim 20$ </tex-math></inline-formula> times lower than in conventional SPECT), the impact of stray-radiation-related noise at these low counts, and the multiple image-degrading processes in SPECT. The conventional reconstruction-based quantification methods are observed to be erroneous for <inline-formula xmlns:mml=http://www.w3.org/1998/Math/MathML xmlns:xlink=http://www.w3.org/1999/xlink> <tex-math notation=LaTeX>$alpha $ </tex-math></inline-formula> -RPT SPECT. To address these challenges, we developed a low-count quantitative SPECT (LC-QSPECT) method that directly estimates the regional activity uptake from the projection data (obviating the reconstruction step), compensates for stray-radiation-related noise, and accounts for the radioisotope and SPECT physics, including the isotope spectra, scatter, attenuation, and collimator–detector response, using a Monte Carlo-based approach. The method was validated in the context of 3-D SPECT with <inline-formula xmlns:mml=http://www.w3.org/1998/Math/MathML xmlns:xlink=http://www.w3.org/1999/xlink> <tex-math notation=LaTeX>${mathrm {^{223}Ra}}$ </tex-math></inline-formula> , a commonly used radionuclide for <inline-formula xmlns:mml=http://www.w3.org/1998/Math/MathML xmlns:xlink=http://www.w3.org/1999/xlink> <tex-math notation=LaTeX>$alpha $ </tex-math></inline-formula> -RPT. Validation was performed using both realistic simulation studies, including a virtual clinical trial, and synthetic and 3-D-printed anthropomorphic physical-phantom studies. Across all studies, the LC-QSPECT method yielded reliable regional-uptake estimates and outperformed the conventional ordered subset expectation-maximization (OSEM)-based reconstruction and geometric transfer matrix (GTM)-based post-reconstruction partial-volume compensation methods. Furthermore, the method yielded reliable uptake across different lesion sizes, contrasts, and different levels of intralesion heterogeneity. Additionally, the variance of the estimated uptake approached the Cramér–Rao bound-defined theoretical limit. In conclusion, the proposed LC-QSPECT method demonstrated the ability to perform reliable quantification for <inline-formula xmlns:mml=http://www.w3.org/1998/Math/MathML xmlns:xlink=http://www.w3.org/1999/xlink> <tex-math notation=LaTeX>$alpha $ </tex-math></inline-formula> -RPT SPECT." @default.
• W4285258313 created "2022-07-14" @default.
• W4285258313 creator A5003805984 @default.
• W4285258313 creator A5003894390 @default.
• W4285258313 creator A5014254460 @default.
• W4285258313 creator A5016752259 @default.
• W4285258313 creator A5017287155 @default.
• W4285258313 creator A5024722162 @default.
• W4285258313 creator A5041734701 @default.
• W4285258313 creator A5043322306 @default.
• W4285258313 creator A5048679648 @default.
• W4285258313 creator A5057343735 @default.
• W4285258313 creator A5067808348 @default.
• W4285258313 creator A5081456414 @default.
• W4285258313 date "2023-01-01" @default.
• W4285258313 modified "2023-10-14" @default.
• W4285258313 title "A Projection-Domain Low-Count Quantitative SPECT Method for ɑ-Particle-Emitting Radiopharmaceutical Therapy" @default.
• W4285258313 cites W1532568685 @default.
• W4285258313 cites W1750292977 @default.
• W4285258313 cites W1890365994 @default.
• W4285258313 cites W1912212332 @default.
• W4285258313 cites W1920946300 @default.
• W4285258313 cites W1974192061 @default.
• W4285258313 cites W1987349811 @default.
• W4285258313 cites W1997928845 @default.
• W4285258313 cites W2002676832 @default.
• W4285258313 cites W2011693978 @default.
• W4285258313 cites W2022687463 @default.
• W4285258313 cites W2031529867 @default.
• W4285258313 cites W2044813020 @default.
• W4285258313 cites W2048042021 @default.
• W4285258313 cites W2050199209 @default.
• W4285258313 cites W2053958583 @default.
• W4285258313 cites W2069629287 @default.
• W4285258313 cites W2086784799 @default.
• W4285258313 cites W2095272243 @default.
• W4285258313 cites W2107955465 @default.
• W4285258313 cites W2121839801 @default.
• W4285258313 cites W2143818728 @default.
• W4285258313 cites W2145720374 @default.
• W4285258313 cites W2154744699 @default.
• W4285258313 cites W2164097181 @default.
• W4285258313 cites W2205667344 @default.
• W4285258313 cites W2238574303 @default.
• W4285258313 cites W2275739917 @default.
• W4285258313 cites W2302322399 @default.
• W4285258313 cites W2465520455 @default.
• W4285258313 cites W2606187374 @default.
• W4285258313 cites W2626822213 @default.
• W4285258313 cites W2752867062 @default.
• W4285258313 cites W2764187530 @default.
• W4285258313 cites W2766810683 @default.
• W4285258313 cites W2799415474 @default.
• W4285258313 cites W2802125673 @default.
• W4285258313 cites W2885633224 @default.
• W4285258313 cites W2938724659 @default.
• W4285258313 cites W2950306824 @default.
• W4285258313 cites W2990493095 @default.
• W4285258313 cites W3007239529 @default.
• W4285258313 cites W3008344257 @default.
• W4285258313 cites W3011215228 @default.
• W4285258313 cites W3015379061 @default.
• W4285258313 cites W3096906134 @default.
• W4285258313 cites W3131399739 @default.
• W4285258313 cites W3170605121 @default.
• W4285258313 doi "https://doi.org/10.1109/trpms.2022.3175435" @default.
• W4285258313 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37201111" @default.
• W4285258313 hasPublicationYear "2023" @default.
• W4285258313 type Work @default.
• W4285258313 citedByCount "4" @default.
• W4285258313 countsByYear W42852583132021 @default.
• W4285258313 countsByYear W42852583132022 @default.
• W4285258313 countsByYear W42852583132023 @default.
• W4285258313 crossrefType "journal-article" @default.
• W4285258313 hasAuthorship W4285258313A5003805984 @default.
• W4285258313 hasAuthorship W4285258313A5003894390 @default.
• W4285258313 hasAuthorship W4285258313A5014254460 @default.
• W4285258313 hasAuthorship W4285258313A5016752259 @default.
• W4285258313 hasAuthorship W4285258313A5017287155 @default.
• W4285258313 hasAuthorship W4285258313A5024722162 @default.
• W4285258313 hasAuthorship W4285258313A5041734701 @default.
• W4285258313 hasAuthorship W4285258313A5043322306 @default.
• W4285258313 hasAuthorship W4285258313A5048679648 @default.
• W4285258313 hasAuthorship W4285258313A5057343735 @default.
• W4285258313 hasAuthorship W4285258313A5067808348 @default.
• W4285258313 hasAuthorship W4285258313A5081456414 @default.
• W4285258313 hasBestOaLocation W42852583131 @default.
• W4285258313 hasConcept C11413529 @default.
• W4285258313 hasConcept C115961682 @default.
• W4285258313 hasConcept C120665830 @default.
• W4285258313 hasConcept C121332964 @default.
• W4285258313 hasConcept C154945302 @default.
• W4285258313 hasConcept C19527891 @default.
• W4285258313 hasConcept C2779200277 @default.
• W4285258313 hasConcept C2780441642 @default.
• W4285258313 hasConcept C2984398910 @default.
• W4285258313 hasConcept C2989005 @default.
• W4285258313 hasConcept C33923547 @default.

• next