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- W4285261580 abstract "Women with hypertrophic cardiomyopathy (HCM) are at an increased risk of heart failure (HF) compared to men. We sought to investigate sex-disaggregated differences in risk factors for heart failure in a large international HCM registry. This is a retrospective study of HCM patients from the Sarcomeric Human Cardiomyopathy Registry. HF composite was used which included: the first occurrence of cardiac transplantation, left ventricular assist device implantation, or New York Heart Association functional class III-IV symptoms. Cox proportional hazards models were fit with a sex interaction term to determine significant differences between sexes. 6,647 (38% women) probands with HCM were included. After a mean follow-up of 6.4 years from first encounter, women had a higher risk of heart failure (HF) composite (HR 1.77; 95% CI 1.56-1.99, p<0.0001). Sarcomere positive status and causative variants in MYBPC3 reduced the risk of the HF composite for women: (HR 0.78; 95% CI 0.62-0.99) and (HR 0.50; 95% CI 0.37-0.69), while for men there was no change in risk: (HR 1.16; 95% CI 0.92-1.45) and (HR 1.11; 95% CI 0.86-1.44); p-heterogeneity=0.016 and <0.0001, respectively. Baseline left ventricular ejection fraction (LVEF) <35% and larger left atrial (LA) size increased the risk of the HF composite for both sexes but to a greater magnitude in men (HR 8.93; 95% CI 5.21-15.28) vs (HR 1.90; 95% CI 1.01-3.57) and (HR 1.50; 95% Ci 1.37-1.65) vs (HR 1.30; 95% CI 1.18-1.44); p-heterogeneity=0.0003 and 0.04, respectively. There are important sex differences in the risk of heart failure in those with HCM, with significant heterogeneity of outcomes based on subgroups defined by genetic and imaging factors." @default.
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- W4285261580 date "2022-01-01" @default.
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- W4285261580 title "Sex Disaggregated Analysis of Risk Factors for Adverse Outcomes in Hypertrophic Cardiomyopathy" @default.
- W4285261580 doi "https://doi.org/10.1016/j.hlc.2022.04.011" @default.
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