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- W4285263357 endingPage "301" @default.
- W4285263357 startingPage "267" @default.
- W4285263357 abstract "Tuberculosis is caused by a bacterium called Mycobacterium tuberculosis (M-tb) which leads to major therapeutic challenges causing several immune dysfunctions by affecting various immune checkpoints. Over the past decades, many research efforts have been made to control tuberculosis infections. However, the etiology of tuberculosis reveals that M-tb has coevolved with human immune response and hijacks various defense mechanisms of natural and synthetic antimicrobial agents contributing to the development of multidrug resistance. Henceforth, the strategy of immunomodulation such as host-directed therapy (HDT) emerges as an important therapeutic modality in treating infectious diseases like tuberculosis. Moreover, the growing understanding of immune checkpoints of bacterial infections leads to the discovery of immuno-modulatory methods and novel drug targets. Thus, the present chapter discusses the efficacy of various immunomodulation against the etiology of M-tb infections and challenges in the development of different classes of immuno-modulatory agents." @default.
- W4285263357 created "2022-07-14" @default.
- W4285263357 creator A5008323356 @default.
- W4285263357 creator A5013639794 @default.
- W4285263357 creator A5062010048 @default.
- W4285263357 date "2022-01-01" @default.
- W4285263357 modified "2023-09-29" @default.
- W4285263357 title "Immuno-Modulatory Role for the Treatment and Management of Tuberculosis" @default.
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